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N-Acetylaspartate
A Unique Neuronal Molecule in the Central Nervous System
by John R. Moffett

N-Acetylaspartate brings together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronal development and functioning.

Contents

  1. A Brief Overview of N-Acetylaspartate and N-Acetylaspartylglutamate
  2. Expression of N-Acetylaspartate and N-Acetylaspartylglutamate in the Nervous System
  3. N-Acetylaspartate Metabolism in Neural Cells
  4. NAA Synthesis and Functional Roles
  5. Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the NAA Transporter
  6. Canvan Disease: Studies on the Knockout Mouse
  7. Functions of N-Acetylaspartate and N-Acetylaspartylglutamate in Brain: Evidence of a Role in Maintenance of Higher Brain Integrative Activities of Information Processing and Cognition
  8. Control of Brain Volume During Hypoosmolality and Hyperosmolality
  9. Physiological Role of N-Acetylaspartate: Contribution to Myelinogenesis
  10. Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canvan Disease
  11. Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease
  12. Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development: A Tissue Culture Study of ASPA KO Mice Brain
  13. Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy
  14. N-Acetyl-L-Aspartate in Multiple Sclerosis
  15. NAA and Higher Cognitive Function in Humans
  16. In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia
  17. N-Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease
  18. Regulation of NAA-Synthesis in the Human Brain In Vivo: Canavan's Disease, Alzheimer's Disease and Schizophrenia
  19. Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis
  20. Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient
  21. Cellular Localization of NAAG
  22. Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber
  23. NAAG as a Neurotransmitter
  24. Glutamate Carboxypeptide ASE II (NAALADase) Inhibition as a Novel Therapeutic Strategy
  25. N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease
  26. N-Acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher Disease
  27. Concluding Remarks

Index

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N-Acetylaspartate
A Unique Neuronal Molecule in the Central Nervous System
by John R. Moffett

2006 375 pages $154.00 + shipping
Texas residents please add 6.75% sales tax

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