N-Acetylaspartate brings together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronal development and functioning.

Contents

1. A Brief Overview of N-Acetylaspartate and N-Acetylaspartylglutamate
2. Expression of N-Acetylaspartate and N-Acetylaspartylglutamate in the Nervous System
3. N-Acetylaspartate Metabolism in Neural Cells
4. NAA Synthesis and Functional Roles
5. Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the NAA Transporter
6. Canvan Disease: Studies on the Knockout Mouse
7. Functions of N-Acetylaspartate and N-Acetylaspartylglutamate in Brain: Evidence of a Role in Maintenance of Higher Brain Integrative Activities of Information Processing and Cognition
8. Control of Brain Volume During Hypoosmolality and Hyperosmolality
9. Physiological Role of N-Acetylaspartate: Contribution to Myelinogenesis
10. Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canvan Disease
11. Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease
12. Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development: A Tissue Culture Study of ASPA KO Mice Brain
13. Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy
14. N-Acetyl-L-Aspartate in Multiple Sclerosis
15. NAA and Higher Cognitive Function in Humans
16. In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia
17. N-Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease
18. Regulation of NAA-Synthesis in the Human Brain In Vivo: Canavan's Disease, Alzheimer's Disease and Schizophrenia
19. Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis
20. Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient
21. Cellular Localization of NAAG
22. Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber
23. NAAG as a Neurotransmitter
24. Glutamate Carboxypeptide ASE II (NAALADase) Inhibition as a Novel Therapeutic Strategy
25. N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease
26. N-Acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher Disease
27. Concluding Remarks

Index

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ORDER NOW N-Acetylaspartate A Unique Neuronal Molecule in the Central Nervous System by John R. Moffett 2006 • 375 pages • $154.00 + shipping Texas residents please add 6.75% sales tax