Nanodevices for the Life Sciences is the first to combine in one book both nanodevice assembly from biomaterials as well as nanodevices of non-biological materials for use in the life sciences, showing how both kinds can be used in the context of nanoscale research.
Nanodevices for the Life Sciences covers the important material classes for device assembly—fullerenes, carbon nanotubes, kinesine microtubules—as well as a wide range of applications, including:
- sensory systems
- analytics
- bioelectronics
- drug delivery
- bioNEMS.
The result is a systematic coverage of all stages of research and development: physics and fundamentals, modeling, device fabrication strategies, material aspects, and applications.
Contents
The Physics and Modeling of Biofunctionalized Nanoelectromechanical Systems
- The Stochastic Dynamics of Micro- and Nanoscale Oscillators in Fluid
- The Physics Describing the Kinetics of Target Analyte Capture on the Oscillator
- Detecting Noise in Noise: Signal-processing Challenges
Mathematical and Computational Modeling: Towards the Development and Application of Nanodevices for Drug Delivery
- RES Avoidance
- A Statistical Model of Nanovector Surface Coverage
- Modeling the Forces of Nanovector Surface Coverage
- Tumoral Vasculature and Hemodynamics
- Receptor–Ligand-mediated Binding
- Intratumoral and Cellular Drug Kinetics and Pharmacodynamics
Nanolithography: Towards Fabrication of Nanodevices for Life Sciences
- Introduction: Engineering Surfaces at the Nanoscale
- Immobilization of Biomolecules for Surface Assays
- Methods for Nanolithography with Proteins
- Detection of Protein Binding at the Nanoscale
- Future Directions
Microcantilever-based Nanodevices in the Life Sciences
- Microcantilevers
- Cantilevers with Integrated Micro- and Nanofluidics
- Applications
- Conclusions and Outlook
Nanobioelectronics
- Bio-self-assembly and Motivation
- Fundamentals of the Bio-building Blocks
- Interconnection, Self-assembly and Device Implementation
- Devices Based on DNA and DNA Bases
- Devices Based on Proteins
DNA Nanodevices: Prototypes and Applications
- DNA as a Material for Nanotechnology
- Simple DNA Devices
- Towards Functional Devices
- Autonomous Behavior
Towards the Realization of Nanobiosensors Based on G-protein-coupled Receptors
- Preparation and Immobilization of GPCRs on Functionalized Surfaces
- Signal Techniques
- Theoretical Approach
- The Impedance Network Model
- Equilibrium Fluctuations
Protein-based Nanotechnology: Kinesin–Microtubule-driven Systems for Bioanalytical Applications
- Kinesin and Microtubule Cell Biology and Biophysics
- Theoretical Transport Issues for Device Integration
- Interaction of Motor Proteins and Filaments with Synthetic Surfaces
- Controlling the Direction and Distance of Microscale Transport
- Cargo Attachment
- System Design Consideration
Self-assembly and Bio-directed Approaches for Carbon Nanotubes: Towards Device Fabrication
- CNTs: Basic Features, Synthesis and Device Applications
- Fabrication of CNT Transistors and Self-assembly Approaches
- In situ CVD Growth
- Selective Deposition of CNTs by SAM-assisted Techniques
- DNA-directed Self-assembly
Nanodevices for Biosensing: Design, Fabrication and Applications
- From Biosensor to Nanobiosensor Devices
- Nanophotonic Biosensors
- Nanomechanical Biosensors
- Conclusions and Future Goals
Fullerene-based Devices for Biological Applications
- Solubility
- Toxicity
- DNA Photocleavage
Nanotechnology for Biomedical Devices
- Nanotechnologies
- Applications
- Discussion and Outlook
Nanodevices in Nature
- Multielectron Processes in Bioelectrochemical Nanoreactors
- Cytochrome Oxidase: A Nanodevice for Respiration
- Photosynthetic Electrochemical Nanoreactors, Nanorecti.ers, Nanoswitches and Biologically Closed Electrically Circuits
- Phototropic Nanodevices in Green Plants: Sensing the Direction of Light
- Membrane Transport and Ion Channels
- Molecular Motors
- Nanodevices for Electroreception and Electric Organ Discharges
- Neurons
Index
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