Neurodegeneration in Multiple Sclerosis conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment.

Neurodegeneration in Multiple Sclerosis features:

• Alzheimer’s disease
• Expanded Disability Status Scale
• brain
• magnetization trasfer ratio
• normal-appearing grey matter

Contents

1. Neuropathological Advances in Multiple Sclerosis
2. Neurophysiology.- MRI Techniques to Assess Neurodegeneration
3. Atrophy
4. T1 Black Holes and Gray Matter Damage
5. Magnetization Transfer Imaging
6. Perfusion MRI
7. Diffusion-Weighted Imaging
8. Proton MR Spectroscopy
9. Functional MRI.-Evaluation of MRI Outcomes
10. Validation of MRI Surrogates
11. Defining Responders and Non-responders
12. Predictive Models in Multimodal Imaging.- Lessons from other Neurodegenerative Diseases
13. Alzheimer’s Disease
14. Other Neurodegenerative Conditions
15. Incorporation of Other Biomarkers.- Designing MS Trials for Neurodegeneration
16. Critical Review of Existing Trials
17. Design for the Next Trials of Neurodegeneration

Index

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