Nimesulide provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents.
Contents
The Discovery, Development and Novel Actions of Nimesulide
- Discovery of R-805 - Nimesulide
- Chemical Synthesis
- Development of Nimesulide
- Physical and Chemical Properties
- Chemical Analysis
- Chemical Reactions of Nimesulide
- Versatile Folmulations
- Novel "Non-Pain" Uses of Nimesulide
- Miscellaneous Uses
Pharmacokinetics of Nimesulide
- Physiochemical Factors Governing the Oral Bioavailability of Nimesulide
- Animal Pharmacokinetics
- Pharmacokinetics in Humans
Pharmaceutical Formulations of Nimesulide
- Formulations for Topical Application
- Formulations for Systemic Administration
- Oral Cyclodextrin Formulations
- Oral Modified-Release Formulations
- Generic Formulations
Pharmacological Properties of Nimesulide
- In Vivo Pharmacological Actions
- Mechanisms of Action of Nimesulide on Pathways of Inflammation Effects of Nimesulide on Arachidonic Acid Metabolism In Vitro, Ex Vivo and In Vivo
- Structural Aspects of Cyclooxygenase (COX) Activity and COX-2 Inhibition by Nimesulide
- Nimesulide and Neutrophil functional Responses
- Analgesic Actions of Nimesulide in Animals and Humans
- Actions on Joint Destruction in Arthritis
- Regulation by Eicosanoids of Cartilage-Synovial-Leucocyte Interactions
- In Vivo Effects of Nimesulide on Cartilage and Bone in Experimental Model Systems
- Actions of Nimesulide on Cartilage Degradation In vitro
Clinical Applications of Nimesulide in Pain, Arthritic Conditions and Fever
- NSAIDs: The Survivors from the Laboratory
- Osteoarthritis: A Leading Target for NSAIDs
- Nimesulide in the Treatment of Osteoarthritis
- Miscellaneous Rheumatic Conditions
- The Analgesic Properties of Nimesulide in Inflammatory Pain
- Nimesulide in the Treatment of Primary Dysmenorrhoea and Other Gynaecological Conditions
- NSAIDs in Sports Medicine
- Acute Pain Models and Conditions
- Adverse Events Encountered in Clinical Trials
Adverse Reactions and Their Mechanisms from Nimesulide
- Nimesulide Safety Profile from Spontaneous Reporting
- Nimesulide Safety from Epidemiological and Population Studies
- Meta-Analysis and Systematic Reviews of Adverse Reactions from Clinical Trials
- Gastrointestinal Tolerance of Nimesulide Compared with other NSAIDs: Clinical Studies
- Clinical Aspects of Nimesulide-Related Hepatic Reactions from Published Case Reports
- Mechanisms of Toxic Reactions
Index
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