Nutrient-Drug Interactions

by Kelly Anne Meckling

Nutrient-Drug Interactions covers food, herbals, and their chemical constituents as contributors to human health through control of metabolism, primarily as they relate to chronic disease development and treatment.

Nutrient-Drug Interactions highlights the ailment being treated or prevented and the targets of therapy. Each chapter provides a comprehensive examination of the macronutrient, micronutrient, and phytochemical impact on drug action and includes advice on modification or supplementation in those cases where diet is a factor. The chapters focus on the molecular mechanism by which a food or chemical is thought to modify disease process and drug behavior. The book describes the roles of genetic variation and polymorphism in determining nutrient/drug responses, how they might be "profiled" to identify those likely to demonstrate specific interactions, and who would benefit from adjuvant or complementary therapies.

Features of Nutrient-Drug Interactions:

• Provides an analysis of hyperlipidemia and dyslipidemia treatment using both drug therapy and dietary modifications
• Discusses how chemoprotective phytochemicals improve metabolic imbalance and can dramatically alter the carcinogenicity of dietary carciogens
• Reviews the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death in neurodegenerative disorders
• Presents observed drug-nutrient interactions that have been noted in the pharmacotherapy of unipolar depression
• Focuses on polymorphism where the intake of a specific nutrient related to that polymorphism affects the pathogenesis of CVD and/or cancer
• Analyzes the present state of nutrigenomic and pharmacogenomic research in relation to human cancer

Contents

1. Diabetes, Obesity and Metabolic Syndrome
2. Hypolipidemic Therapy: Drugs, Diet, and Interactive Effects
3. Phytochemicals, Xenobiotic Metabolism, and Carcinogenesis
4. Nutrient and Phytochemical Modulation of Cancer Treatment
5. Role of Nutritional Antioxidants in the Prevention and Treatment of Neurodegenerative Disorders
6. Nutrients and Herbals in the Pharmacotherapy of Unipolar/Major Depression
7. Supplements and Anesthesiology
8. Nutrient and Drug Responsive Polymorphic Genes as Nutrigenomic Tools for Prevention of Cardiovascular Disease and Cancer
9. Nutrigenomics and Pharmacogenomics of Human Cancer: On the Road from Nutrigenetics and Pharmacogenetics

Index

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