Parkinson's Disease emphasizes both the importance of early diagnosis and the search for more effective therapies.

It is an essential reference on the journey toward deciphering its cause and discovering a cure.

Recent research is leading to an ever-increasing range of investigative approaches whose aim is to achieve effective neuroprotective or neurorestorative treatment for individuals affected by Parkinson's disease.

New directions under investigation reach beyond traditional pharmacological approaches to venture into innovative surgical methods, gene therapy, stem cell therapy, and neurotransplantation.

Parkinson's Disease provides state-of-the-art information on all aspects of Parkinson's disease.

It covers the historical background, neuropathological and neurophysiological characteristics, epidemiological aspects, clinical features, current treatment approaches, and potential therapeutic methods.

Novel models are included to simplify more complex concepts.

Contents:

1. Overview
   • James Parkinson, Jennifer G. Goldman and Christopher G. Goetz
   • Paralysis Agitans - Refining the Diagnosis and Treatment, Larry Elmer
   • The Role of Dopamine in Parkinson's Disease: An Historical Review, L. Charles Murrin
   • Parkinson's Disease: Where Are We?, Ajit Kumar, Zhigao Huang, and Donald B. Calne

2. Epidemiology
   • Epidemiology of Parkinson's Disease: An Overview, Monica Korell and Caroline M. Tanner
   • Environmental Toxins and Parkinson's Disease, Marcia H. Ratner and Robert G. Feldman
   • Rural Environment and Parkinson's Disease, Daniel Strickland
   • Industrial and Occupational Exposures and Parkinson's Disease, Brad A. Racette
   • Tetrahydroisoquinolines and Parkinson's Disease, Mark S. LeDoux
   • Xenobiotic Metabolism and Idiopathic Parkinson's Disease, L. Cartwright, D.B. Ramsden, S.W. Smith, R.H. Waring, R.B. Parsons, S.L. Ho, and A.C. Williams
   • Progressive Neurodegeneration in the Chronic MPTP/Probenecid Model of Parkinson's Disease, Yuen-Sum Lau

3. Genetics
   • Alpha Synuclein and Parkinson's Disease, Lawrence I. Golbe
   • Parkin and It's Role in Parkinson's Disease, Thomas Gasser
   • Heredofamilial Parkinsonism, Pramod Kumar Pal and Zbigniew K. Wszolek
   • Other Mutations: Their Role in Parkinson Disease, Nathan Pankratz and Tatiana Foroud

4. Clinical Features of Parkinson's Disease
   • Classical Motor Features of Parkinson's Disease, Kelvin L. Chou and Howard I. Hurtig
   • Clinical Evaluation and Treatment of Gait Disorders in Parkinson's Disease, Yacov Balash, Jeffery M. Hausdorff, Nir Giladi
   • Non-Motor Symptoms
   • Sensory Symptoms and Sensorimotor Distortion in Parkinson's Disease, Padraig O'Suilleabhain
   • Pain in Parkinson's Disease, Blair Ford
   • Fatigue: A Common Comorbidity in Parkinson's Disease, Carol Ewing Garber and Joseph H. Friedman
   • Sleep Disorders in Parkinson's Disease, Svenja Happe and Claudia Trenkwalder
   • Visual Function in Parkinson's Disease, Robert L. Rodnitzky
   • Visuocognitive Dysfunctions in Parkinson's Disease, Andrea Antal, Walter Paulus, and Ivan-Bodis Wollner
   • Olfactory Dysfunction in Parkinson's Disease and Parkinsonian Syndromes, Katerina Markopoulou
   • Autonomic Dysfunction
   • Gastrointestinal Dysfunction in Parkinson's Disease, Ronald F. Pfeiffer
   • Urinary Dysfunction in Parkinson's Disease, Carlos Singer
   • Sexual Dysfunction, Cheryl Waters and Janice Smolowitz
   • Cardiovascular Automomic Dysfunction in Parkinson's Disease and Parkinsonian Syndromes, Christopher Mathias
   • Disorders of Thermoregulation in Parkinson's Disease, Thomas L. Davis
   • Respiratory Dysfunction, Holly Shill
   • Behavioral Dysfunction
   • Depression in Parkinson's Disease, Steven P. Wengel, Daryl Bohac , and William J. Burke
   • Anxiety and Parkinson's Disease, Oksana Suchowersky and Michael Trew
   • Dementia in Parkinson's Disease, Anne L. Barba , Eric S. Molho, Donald S. Higgins, Anthony J. Santiago, and Stewart A. Factor

5. Pathophysiology of Parkinson's Disease
   • Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson's Disease Research, Giselle M. Petzinger and Michael W. Jakowec
   • The Neuropathology of Parkinson's Disease and Other Parkinsonian Disorders, Christopher A. Robinson and Ali H. Rajput
   • Pathophysiology of Motor Disorder, Gaetan Garraux and Mark Hallett
   • Neurochemical Pathology
   • MPTP Disrupts Dopamine Receptors and Dopamine Transporters, Manuchair Ebadi and Jaturaporn Chagkutip
   • Pathophysiology of Parkinson's Disease, Neurochemical Pathology: Other Transmitters, Yoshikuni Mizuno
   • Theories of Pathogenesis
   • Metallothionein Isoforms Attenuate Peroxynityrite-Induced Oxidative Stress in Parkinson's Disease, Manuchair Ebadi, Sushil Sharma, Sawitri Wanpen, and Shaik Shavali
   • Excitotoxicity in Parkinson's Disease, James G. Greene and J. Timothy Greenamyre
   • Inflammation, Roger Kurlan
   • Cell Death in Parkinson's Disease, Ciaran J. Faherty and Richard J. Smeyne
   • Weaver Mutant Mouse in Progression of Neurodegeneration in Parkinson's Diseae, Maunchair Ebadi, Sushil Sharma, Amornpan Ajjimapon, and Scott Manum

6. Diagnosis of Parkinson's Disease
   • Differential Diagnosis of Parkinson's Disease, Serena W. Hung. and Anthony E. Lang
   • Diagnostic Criteria for Parkinson's Disease, Daniel Tarsy
   • Neuroleptic-Induced Movement Disorders, Manuchair Ebadi
   • The Placebo Effect in Parkinson's Disease, Sarah C. Lidstone, Raul de la Fuente-Fernandez, and A. Jon Stoessl
   • Dopamine Transporter Imaging Using SPECT in Parkinson's Disease, Danna Jennings, Ken Marek, and John Seibyl
   • MR Imaging of Parkinsonism, James Wood
   • Clinical Batteries, Erwin B. Montgomery, Jr.
   • Rating Scales, Kathleen M. Shannon

7. Treatment of Parkinson's Disease
   • Symptomatic Medical Treatment
   • Treatment of Parkinson's Disease with Anticholinergic Medications, Bahman Jabbari and Rene Pazdan
   • Amantadine, Kelly E. Lyonsand Rajesh Pahwa
   • The Role of MAO-B Inhibitors in the Treatment of Parkinson's Disease, John Bertoni and Larry Elmer
   • Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson's Disease, Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser
   • Symptomatic Treatment of Parkinson's Disease: Levodopa, John L. Goudreau and J. Eric Ahlskog
   • Dopamine Agonists in Parkinson's Disease, Sandra Kuniyoshi and Joseph Jankovic
   • Surgical Treatment
   • Parkinson's Disease: Surgical Treatment - Stereotactic Procedures, Yasuhiko Baba, Robert E. Wharen, Jr., and Ryan J. Uitti
   • Neurotransplanation in Parkinson's Disease, Ronald F. Pfeiffer
   • Non-Pharmacological Treatment Modalities
   • The Role of Physical Therapy in Management of Parkinson's Disease, Rose Wichmann
   • Swallowing Function in Parkinson's Disease, Lisa A. Newman
   • Restorative and Psychosocial Occupational Therapy in Parkinson's Disease. Surya Shah and Ann Nolen
   • Music Therapy for People with Parkinson's, Sandra L. Holten
   • Treatment Issues
   • Pathogenesis of Motor Response Complications in Parkinson's Disease: "Mere Conjectural Suggestions" and Beyond, Leo Verhagen Metman
   • Treatment of Early Parkinson's Disease, John C. Morgan and Kapil D. Sethi
   • Moderate Parkinson's Disease , John E. Duda and Matthew B. Stern
   • Management of Advanced Parkinson's Disease, James W. Tetrud
   • Potential Future Therapy
   • Future Symptomatic Therapy in Parkinson's Disease, Ruth Djaldetti and Eldad Melamed
   • Restorative Therapy in Parkinson's Disease, Joel M. Trugman
   • Gene Therapy for Parkinson's Disease, Ronald J. Mandel, Edgardo Rodriguez, M. Angela Cenci, Stuart E. Leff, Fredric Manfredsson, and Carmen S. Peden
   • Translating Stem Cell Biology to Regenerative Medicine for Parkinson's Disease, Dennis A. Steindler
   • Clinical Trials
   • Alternative Drug Delivery in the Treatment of Parkinson's Disease, Pierre J. Blanchet
   • The Role and Design of Clinical Trials for Parkinson's Disease, Andrew Siderowf and Stanley Fahn
   • Positron Emission Tomography in Parkinson's Disease, John R. Adams and A. Jon Stoessl

8. Social Issues in Parkinson's Disease
   • Economics of Parkinson's Disease, Katia Noyes and Robert G. Holloway
   • Informal Caregivers: A Valuable Part of the Health Care Team, Kirsten Maier and Susan Calne
   • Quality of Life in Parkinson's Disease: A Conceptual Model, Mickie D. Welsh
   • The Evolution and Potential of the National Parkinson Organizations: A Brief Overview, Ruth A. Hagestuen

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ORDER NOW Parkinson's Disease edited by Manuchair Ebadi and Ronald F. Pfeiffer 2004 • 1,080 pages • $218.95 + shipping Texas residents please add 6.75 % sales tax