Particulate Interactions in Dry Powder Formulations for Inhalation combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules.).

Contents:

1. Interparticulate Forces
   • Van der Waals forces
   • Electrostatic forces
   • Capillary forces
   • Mechanical interlocking
   • Factors affecting particulate interactions

2. Interparticulate Forces in Pharmaceutical Powders
   • Mechanical properties
   • Electrical properties
   • Water vapour condensation
   • Particle morphology
   • Polymorphism and crystallinity
   • Processing conditions
   • Flow properties
   • Powder mixing
   • Agglomeration

3. Medicinal Aerosols
   • Aerosol deposition in the respiratory tract
   • Delivery devices
   • Physiology of the human respiratory tract
   • Breathing patterns
   • Physico-chemical properties of drug particles

4. Particle Interactions with Air Streams
   • Drag forces of air streams
   • Particle entrainment
   • Particle dispersion
   • Factors affecting entrainment and dispersion of particles in air streams

5. Particulate Interactions in Dry Powder Aerosols
   • Generation of aerosol dry powders
   • Carrier particles
   • Carrier-free formulations
   • Particulate interactions between the drug and carrier particles

6. Measurement of Cohesion, Adhesion and Dispersion of Powders
   • Cohesion of powders
   • Adhesive forces
   • Aerodynamic methods
   • Characterisation of aerodynamic properties of medicinal aerosols

7. Physical Characterisation of Pharmaceutical Powders
   • Molecular properties
   • Particulate properties
   • Bulk properties of solids

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