Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications.

Part I of Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules addresses comparative strengths and weaknesses of various nucleoside homologues.

Part II of Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules addresses specific translational or clinical applications for PNA and related antisense biomolecules.

Contents

Research Applications

1. The Many Faces of PNA
2. Modulation of Nucleic Acid Information Processing by PNAs: Potential Use in Anti-Viral Therapeutics
3. Targeted Gene Delivery: The Role of Peptide Nucleic Acid.- Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology
4. Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide
5. Analogs and Radionuclides
6. Morpholinos and PNAs Compared
7. Chemistry of Locked Nucleic Acids (LNA): Design, Synthesis and Bio-Physical Properties
8. Recent Applications of RNA Interference (RNAi) in Mammalian Systems

Clinical Applications

9. Peptide Nucleic Acids as Epigenetic Inhibitors of HIV-1
10. Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology
11. PNAs as Novel Cancer Therapeutics
12. Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids:A New Strategy for Gene Therapy
13. Locked Nucleic Acids (LNA) and Medical Applications
14. Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function
15. Peptide Nucleic Acids: Cellular Delivery and Recognition of DNA and RNA Targets
16. The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy
17. Gene Silencing through RNA Interference: Potential for Therapeutics and Functional Genomics
18. Transcriptional Activation of Human CREB Gene Promoter Using Bis-PNA (Peptide Nucleic Acid)

Index

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