Pesticide, Veterinary and Other Residues in Food reviews the wealth of recent research on assessing and managing the risks from pesticide, veterinary, and other chemical residues in food.
Part 1 covers the assessment and management of risks, with individual chapters on genetic susceptibility to dietary carcinogens, good agricultural practice and HACCP systems, targeted and rapid methods for analysing residues in food and ways of assessing the mutagenicity of chemicals in food.
Part 2 looks at veterinary residues, covering their safety, toxicology and detection.
Part 3 examines pesticides, with chapters on surveillance and detection methods for fungicides and herbicides.
In the final part, there are chapters summarising a wide range of other chemical residues in food, from xenostrogens/endocrine disruptors and dietary estrogens to polycyclic aromatic hydrocarbons, dioxins and polychlorinated biphenyls.
Contents
Part 1: ASSESSING AND MANAGING RISKS
Genetic susceptibility to dietary carcinogens
- Diet and cancer
- Dietary carcinogens and anticarcinogens: mycotoxins, aeterocyclic amines, aromatic hydrocarbons, N-nitroso compounds and phytochemicals
- Genetic influences on carcinogen-metabolising enzymes
- Evidence of diet-gene interactions
Assessing the mutagenicity of chemicals in food: the case of pesticides
- Mutagenicity test programmes
- Criteria for the testing of pesticides
- Selecting appropriate tests
- Assessing dose-response relationships
- Developing test methodologies
- Appendix: the genotoxicity tests listed in EU Directive / Annex V
The impact of chemical residues: the case of polychlorinated biphenyls (PCBs)
- Introduction: risks posed by organohalogen compounds
- Organohalogens as neurotoxins
- Neurobehavioural consequences of PCB exposure
- Molecular mechanisms of organohalogen-induced toxicity
Targeted and rapid methods in analysing residues in food
- The principles of immunoassays
- The use of immuno-affinity chromatography
- Developing immunoassays to detect residues in food and water
- Recent developments in immunoassays
- Recent developments in immuno-affinity chromatography
- The use of immunosensors in residue analysis
Good agricultural practice and HACCP systems in the management of pesticides and veterinary residues on the farm
- Safety issues in the food supply chain
- Good agricultural practice
- The Hazard Analysis and Critical Control Point (HACCP) system
- The HACCP study
- Implementing and maintaining HACCP systems
PART 2: VETERINARY RESIDUES
Assessing the safety of veterinary drug residues
- Types of toxicity study
- Setting maximum residue limits (MRLs) for veterinary drugs in the EU
- Setting MRLs for particular foods in the EU
- International regulation: the role of the Joint Expert Committee on Food Additives and Contaminants (JECFA)
The toxicology of particular veterinary drug residues
- Griseofulvin
- Â-Lactam antibiotics: penicillins and cephalosporins
- Macrolide antibiotics: spiramycin, tylosin and tilmicosin
- Aminoglycosides
- Fluoroquinolones
- Sulfadimidine (sulfamethazine)
- Carbadox and olaqindox
- Furazolidine and related compounds
- Chloramphenicol
- Ivermectin and related compounds
- Tranquillisers: xylazine and azerepone
- Carazolol
The rapid detection of veterinary drug residues
- Veterinary medicinal products
- Methods for detecting residues
- Validating detection methods
- Rapid on-line confirmation of different veterinary residues
New techniques for the rapid detection of growth promoters in farm animals
- Detecting the use of growth promoters
- Existing detection techniques and their limitations
- The use of immunosensors to detect growth promoters
- Key issues in developing new biosensors
The rapid detection of coccidiostat drug residues in farm animals
- The use of anticoccidial drugs in poultry farming
- The use of time-resolved fluoroimmunoassays (TR-FIAs)
- Screening for coccidiostat residues by automated TR-FIAs
PART 3: PESTICIDES
Surveillance for pesticide residues
- Pesticide regulation in the US
- Sample collection, preparation and analysis
- Results from pesticide surveillance programs
- Interpreting the results of pesticide surveillance programs
The rapid detection of pesticide residues
- Detecting pesticides: physiochemical methods
- Detecting pesticides: biological methods
- The principles of biosensors
- Developing low-cost biosensors
- Using biosensors: pesticide residues in grain, fruit and vegetables
Detecting residues of urea and carbamate pesticides
