This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular, and physicochemical factors influencing the efficacy and utilization of pharmaceutical aerosols and analyzes the latest science and developments in the generation, administration, and characterization of these compounds—showcasing current clinical applications, the efficiency and limitations of major aerosol products, and emerging aerosol therapies impacting the field.

Contents

1. Factors Governing Aerosol Deposition and Targeting in the Lung
   1. Physiology of the Airways
   2. Pharmacology of Therapeutic Aerosols
   3. Targeting by Deposition
   4. Drug Targeting to the Lung: Chemical and Biochemical Considerations
   5. Lung Deposition Simulation
   6. Practical Aspects of Imaging Techniques Employed to Study Aerosol Disposition and Clearance
   7. Pharmacokinetics and Pharmacodynamics of Drugs Delivered to the Lungs

2. Methods of Generation, Administration, and Characterization of Aerosols
   8. Theoretical Principles and Devices Used to Generate Aerosols for Research
   9. The Design and Development of Inhalation of Drug Delivery Systems
   10. Aerosol-Filling Equipment for the Preparation of Pressurized-Pack Pharmaceutical Formulations
   11. Methods of Aerosol Particle Size Characterization
   12. Summary of Common Approaches to Pharmaceutical Aerosol Administration

3. Clinical Aspects of Aerosol Administration and Future Perspectives
   13. Therapeutic Aerosols: An Overview from a Clinical Perspective
   14. Aerosolized Pentamidine for Treatment and Prophylaxis of Pneumocystis carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome
   15. The Application of Aerosolized Antimicrobial Therapies in Lung Infections
   16. Gene Delivery to the Lung
   17. Recent Advances Related to the Systemic Delivery of Therapeutic Molecules by Inhalation
   18. Modulated Drug Therapy with Inhalation Aerosols: Revisited
   19. Pulmonary Delivery Technology: Advances of the Last Decade and Potential for the New Millennium

Index

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