Pharmacological Perspectives of Toxic Chemicals and Their Antidotes provides up-to-date pharmacological and toxicological information on the following and includes their mechanism of toxicity:

• chemical warfare agents
• industrial chemicals
• environmental toxins
• metalloid and array of miscellaneous agents

This book covers topics of current interest like pharmacology of nitric oxide, oxidative stress, modulation of brain cytochrome p450s by environmental chemicals, modalities of nociception and the underlying molecular mechanisms including areas of pharmacology and toxicological interest never discussed in detail like capsaicin, cyanide, arsenic toxicity and cyanobacterial toxin etc.

A number of antidotes, which are being used, or currently being investigated, for the treatments of the above toxicants are also discussed in this book.

Contents

Chemical and Biological Weapons

1. Physiological and Neurophysiological Sequelae of Chemical Terrorism
2. Six Current or Potential Skin Decontaminants for Chemicals Warfare Agent Exposure
3. Prophylaxic Efficacy of Amifostine and DRDE-07 Against Sulfur Mustard Administered by Various Routes
4. Detection, Decontamination, and Detoxification of Chemical Warfare Agents Using Polyurethane Enzyme Sponges
5. In Search of an Ideal Bioscavenger for Organophosphate Chemical Warfare Agent Toxicity
6. Biomarkers in Detection of Sulfur Mustard
7. Bacterial Enzymes – Potential Applications for Personnel/Casualty Decontamination Against G, V, and HD Chemical Agents
8. Toxicity Evaluation of Thiodiglycol
9. Insights on Cyanide Toxicity and Methods of Treatment
10. The Virulence Components of Plague Bacilli: A Potent Biological Weapon
11. Anthrax: Bacteriology, Clinical Presentations and Management
12. Cyanobacterial Toxins: Effects and Control Measures
13. Toxicology and Pharmacology of Brevetoxins

Toxic Chemicals and Their Mode of Action

14. Non-Cholinesterase Actons of Anticholinesterases
15. Toxicological Review of Capsaicin as a Weapon
16. Modalities of Nociception and the Underlying Molecular Mechanisms
17. Chronic Arsenic Poisoning: Target Organ Toxicity, Diagnosis and Treatment
18. Mechanisms Involved in the Regulation of Free Radical Generation from Neutrophils
19. Toxicological Consequences of Modulaiton of Brain Cytochrome P450s by Environmental Chemicals

Pharmacology of CBW Antidotes

20. Development of Treatments for Intoxication by Botulinum Neurotoxin
21. Human Butyrylcholinesterase: A Future Generation Antidote for Protection Against Organophosphate Agents
22. Management of Commonly Encountered Drug Poisonings
23. a-ketoglutarate: A Promising Antidote to Cyanide Poisoning
24. Oxidative Stress in Alzheimer´s Disease and Cerebral Ischemia: Implications for Antioxidant Treatment
25. Succimer and its Analogues: Antidotes for Metal Poisoning
26. ECGs and Metabolic Networks: An in silico Exploration of Cyanide-Caused Cardiac Toxicity

Index

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