by Emil W. Ciurczak
and James K. Drennen III

Discussing the theory, instrumentation, validation, and implementation of near-infrared spectroscopy for pharmaceutical and medical applications, this reference showcases a diverse range of contemporary methods for the production, screening, and analysis of new drug products and pharmaceuticals, as well as medical diagnostics and monitoring.

Presents current approaches in near-infrared spectroscopy (NIR) to monitor and control multiple phases of the drug manufacturing process—from bulk raw materials to tablets for final release!

Detailing the latest innovations, Pharmaceutical and Medicinal Applications of Near-Infrared Spectroscopy illustrates:

• techniques to regulate the moisture content, particle size, and uniformity of tablets
• pelletization technology for oral dosage form development
• NIR instrument qualification
• film coating of beads and granules
• regulation standards for pharmaceutical NIR
• quality control for active pharmaceutical ingredients (APIs)
• validation of analytical and process control methods

Pharmaceutical and Medicinal Applications of Near-Infrared Spectroscopy is a timely source for analytical and pharmaceutical chemists; quality control and process engineers; biotechnologists and medical researchers; and upper-level undergraduate and graduate students in these disciplines.

Contents

1. Basic Principles and Theory
2. Instrumentation
3. Blend Uniformity Analysis
4. Granulation, Drying, and Coating
5. Pharmaceutical Assays
6. Validation Issues
7. Medical Applications

Index

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