This unique reference examines the modern pharmaceutical compacting techniques used to form tablets out of powders—describing the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles.

Contents

1. Interparticulate Bonding Characteristics of Pharmaceutical Compacts
   • Interparticulate Attraction Mechanisms
   • The Importance of Intermolecular Bonding Forces and the Concept of Bonding Surface Area

2. Characterization of the Compression Process
   • Porosity-Pressure Functions
   • Force-Displacement and Network Measurements
   • Viscoelastic Models
   • Application of Percolation Theory and Fractal Geometry to Tablet Compaction

3. Characterization of Compact Properties
   • Mechanical Strength
   • Tablet Surface Area
   • Rationale for and the Measurement of Tableting Indices

4. Material Properties of Importance for Powder Volume Reduction and Compact Strength
   • Particle Dimensions
   • Mechanical Properties
   • Granule Properties
   • Modeling the Compression Behavior of Particle Assemblies from the Mechanical Properties of Individual Particles

5. Compaction Properties of Excipients and Powder Mixtures
   • Materials for Direct Compaction
   • Compaction Properties of Binary Mixtures
   • Lubricant Sensitivity
   • The Development and Optimization of Tablet Formulations Using Mathematical Methods

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