Pharmaceutical Profiling in Drug Discovery for Lead Selection focuses on how to increase the efficiency of drug discovery and development.

Written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences, this book details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Contents

1. Absorption Prediction
2. Predicting Molecular Physical Properties
3. In Silico Transporter Modeling and Its Application in Drug Discovery
4. Models for Cytochrome P450-Mediated Metabolism
5. Future of In Silico Methods in Toxicology
6. Solubility in Water and DMSO: Issues and Potential Solutions
7. Measurements of Lipophilicity and Acid/Base Character Using HPLC Methods
8. How Do We Study Oxidative Chemical Stability in Discovery? Some Ideas, Trials, and Outcomes
9. Physiochemical Methods for Estimating Permeability and Related Properties
10. Cultured Epithelial Cell Assays Used to Estimate Intestinal Absorption Potential
11. In Vitro Cell-based Assays for Estimating the Effects of Efflux Transporters on Cell Permeation
12. In Vitro Models for Estimating Hepatobiliary Clearance
13. Challenges in Drug Discovery: Lead Optimization and Prediction of Human Pharmacokinetics
14. Free Drug! The Critical Importance of Plasma Protein Binding in NewDrug Discovery
15. Use of In Vitro ADME Screens to Develop Orally Bioavailable and CNS-Permeable Neuropeptide Y Y5 Antagonists
16. Applying Computational and In Vitro Approaches to Lead Selection
17. Strategies for In Silico and Experimental Screening of Physiochemical Properties
18. The Challenge of Quality in Candidate Optimization
19. A Comprehensive Strategy for ADME Screening in Drug Discovery
20. Scientific, Educational, and Communication Issues Associated with Integrating and Applying Drug-Like Properties in Drug Discovery

Index

Methods for Structural Analysis of Protein Pharmaceuticals is Volume 3 in the series: Biotechnology: Pharmaceutical Aspects. Other volumes in this series include:
Volume 2: Lyophilization for Biopharmaceuticals
Volume 3: Methods for Structural Analysis of Protein Pharmaceuticals

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