Molecular Biology Book from C.H.I.P.S.

by Alexander Bürkle

Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated.

Extensive bibliography is given in each chapter.

Graduate students, postdocs, and established researchers.


1. Enzymes in Poly(ADP-Ribose) Metabolism

  • Overview of the Enzymes of Poly(ADP-Ribose) Metabolism
  • The PARP Family of Proteins
  • Poly(ADP-Ribose) Glycohydrolase (PARG)
  • ADP-Ribosyl Protein Lyase

2. Structure-Function Relationship

  • PARP-2, the Closes PARP-1 Relative
  • PARP-2, a Novel DNA-Damage Dependent pol(ADP-Ribose) Polymerase
  • The Crystal Structure of the Mouse PARP-2 Catalytic Domain
  • PARP-2 Localises Broadly Across the Centromere during the Prometaphase and Metaphase Stages
  • Radiosensitivity of PARP-2 Deficient Mice and Cells
...and many more

3. Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals

  • PARG Gene Structure and Expression
  • Biological Function of PARG
  • PARGGene Disruption in ES Cells
  • Embryonic Development in PARG Mice
  • Proliferation of PARG110-Depleted Fibroblast Cells
  • Immortalization Potential of PARG Cells

4. DNA Damage Signaling through Poly(ADP-Ribose)

  • The Different Steps of Signaling
  • Protein Targeting by Poly (ADP-Ribose)
  • Polymer-Binding 'Reprograms' Domain Functions of Proteins

5. Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity

  • Dynamic Nature of Poly(ADP-Ribore) Metabolism Due to the Interplay between PARP and PARG
  • Control of Cellular Function, Including Centrosome Duplication, by Poly(ADP-Ribosyl)ation
  • Poly(ADP-Ribose) Metabolism in Drosophila Melanogaster

6. Functional Interactions of PARP-1 with p53

  • Sequence Analysis and Functional-Structural Features of p53
  • Post-Translational Regulation of p53 by Enzymatic Poly(ADP-Ribosyl)ation
  • Primary Structure of Poly(ADP-Ribose)Polymerase-1 and Its Multiple Functional Domains
  • Functional Interactions of PARP-1 with p53 and Genomic Integrity
  • Functional Interactions of PARP-1 with p53 in Apoptotic Cells
  • Functional Regulation of p53 by Covalent Poly(ADP-Ribosyl)ation

7. Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1

  • PCNA: A Protein with Many Partner p21 Regulates the Activity of PCNA
  • Effect of the Interaction between PARP-1 and PCNA

8. PARP-1 as Novel Coactivator of NF-kB in Inflammatory Disorders

  • The Role of PARP-1 in Inflammatory Disorders
  • The Switch from Homeostasis to Disorders
  • Nuclear Transcription Factor kappa B
  • Dysregulation of NF-kB in Disease
  • The Role for PARP-1 as a Novel Coactivator of NF-kB
  • Poly(ADP-Ribosyl)ation Activity and NF-kB-Dependent Gene Expression
  • Model for the Function of the Transcriptional

9. PARP and Epigenetic Regulation

  • Several Epigenetic Modifications Work Together in the Regulation of Gene Expression
  • Inhibition of Poly(ADP-Ribosyl)ation Induces DNA hypermethylation
  • Molecular Mechanism(s) Connecting DNA Methylation to Poly(ADP-Ribosyl)ation: A Puzzle to Solve

10. PARP and the Release of Apoptosis-Inducing Factor from Mitochondria

  • PARP-1 and Nuclear Death Signals
  • Poly(ADP-Ribose) Glycohydrolase (PARG)
  • Mitochondrial Participation in Cell Death Cascades
  • Apoptosis-Inducing Factor
  • AIF-Mediated Cell Death
  • Mitochondrial Release of AIF
  • Poly(ADP-Ribose) (PAR) Polymer-Mediated Cellular Response

11. Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis

  • Introduction: DNA Fragmentation in Apoptosis
  • Poly(ADP-Ribosyl)ation-Regulated Endonuclease: Not Such a New Observation
  • Identification of DNAS1L3 as the Poly(ADP-Ribosyl)ation
  • Catalytic Properties of DNAS1L3
  • Poly(ADP-Ribosyl)ation and Inactivation of Recombinant DNAS1L3 by PARP-1 in Vitro
  • DNAS1L3 Mediates Internucleosomal DNA Fragmentation during Drug of or TNF-Induced Apoptosis
...and many more

Chapters 12-19


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by Alexander Bürkle
2006 246 pages $158.00 + shipping
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