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Pharmaceutical Dosage Forms book from C.H.I.P.S.

Preformulation in Solid Dosage Form Development
edited by
Moji Christianah Adeyeye

Covering every topic of critical importance to the preformulation stages of development, Preformulation in Solid Dosage Form Development covers basic and applied principles for the characterization of new drug compounds and substances-considering the identification, stability, structure, and mechanisms of drug candidates during preformulation through Phase I of clinical trials.

Features:

  • outlines a preformulation program that can be applied to the majority of drug candidates
  • contains rational designs for the structure of formulation studies
  • covers preformulation design and prediction using artificial neural networks
  • includes novel methods to determine the physical and chemical stability of new formulations
  • reviews the content and format of the preformulation report

Contents

Introduction

  • Introduction and Overview to the Preformulation Development of Solid Dosage Forms

Preliminary Preformulation

  • Accelerating the Course of Preliminary Preformulation Through Prediction of Molecular Physical Properties and Integrated Analytical Data Management
  • Prediction of Crystallographic Characteristics
  • Salt Selection for Pharmaceutical Compounds
  • Intelligent Preformulation Design and Predictions Using Artifical Neural Networks

Profiling the Drug Substance

  • Developing a Profile of the Active Pharmaceutical Ingredient
  • Particle Morphology and Characterization in Preformulation
  • Preparation and Identification of Polymorphs and Solvatomorphs
  • X-Ray Diffraction Methods for the Characterization of Solid Pharmaceutical Materials
  • Spectroscopic Methods and Calorimetric Methods for the Characterization of Drug Substances
  • Thermal Analysis and Clorimetric Methods for the Characterization of New Crystal Forms
  • Solubility Methods for the Characterization of New Crystal Forms

Development of the Ideal Formulation

  • Overview of the Solid Dosage Form Preformulation Program
  • Drug-Excipient Interaction Occurrences During Solid Dosage Form Development
  • Methodology for the Evaluation of Chemical and Physical Interactions Between Drug Substances and Excipients
  • Dissolution Testing

Beyond Preformulation

  • Structure, Content, and Format of the Preformulation Report
  • Significance of Drug Substance Physicochemical Properties in Regulatory Quality by Design

Index

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Preformulation in Solid Dosage Form Development
edited by Moji Christianah Adeyeye
2008 596 pages $228.95 + shipping
Texas residents please add 6.75 % sales tax

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