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Principles of Neural Science
Fourth Edition
by Eric R. Kandel

Completely updated and reorganized, Principles of Neural Science, Fourth Edition provides an authoritative introduction to the brain: its structure, function, development, and control of behavior.

Principles of Neural Science presents an in-depth summary of the state of the science as well as a full discussion of historical issues.

Neuroanatomy, cell and molecular mechanisms of signaling, development and plasticity are thoroughly described in the context of cognitive approaches to behavior.

Principles of Neural Science is an essential reference for your clinical practice or research.

This edition features expanded treatment of:

  • Ion channel mechanisms, including new structural views of both voltage-gated and transmitter-gated channels involved in neuronal signaling development of the nervous system-covering neuroinduction and patterning, the generation of cell lineages, cell-cell adhesion, axon outgrowth, target recognition, and synapse formation
  • The genetic basis of neurological and psychiatric diseases-Huntington's disease, Alzheimer's disease, muscular dystrophy, depression, and schizophrenia cognitive neuroscience of perception, planning, action, motivation, and memory
  • And the new, spectacular color art program reinforces basic concepts and principles with remarkable clarity. Principles of Neural Science, Fourth Edition provides the most current, comprehensive coverage of this exciting and fast-moving field.


  1. The Neurobiology of Behavior
    1. The Brain and Behavior
    2. Nerve Cells and Behavior
    3. Genes and Behavior

  2. Cell and Molecular Biology of the Neuron
    1. The Cytology of Neurons
    2. Synthesis and Trafficking of Neuronal Protein
    3. Ion Channels
    4. Membrane Potential
    5. Local Signaling: Passive Electrical Properties of the Neuron
    6. Propagated Signaling: The Action Potential

  3. Elementary Interactions Between Neurons: Synaptic Transmission
    1. Overview of Synaptic Transmission
    2. Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission
    3. Synaptic Integration
    4. Modulation of Synaptic Transmission: Second Messengers
    5. Transmitter Release
    6. Neurotransmitters
    7. Diseases of Chemical Transmission at the Nerve-Muscle Synapse: Myasthenia Gravis

  4. The Neural Basis of Cognition
    1. The Anatomical Organization of the Central Nervous System
    2. The Functional Organization of Perception and Movement
    3. Integration of Sensory and Motor Function: The Association Areas of the Cerebral Cortex and the Cognitive Capabilities of the Brain
    4. From Nerve Cells to Cognition: The Internal Cellular Representation Required for Perception and Action

  5. Perception
    1. Coding of Sensory Information
    2. The Bodily Senses
    3. Touch
    4. The Perception of Pain
    5. Constructing the Visual Image
    6. Visual Processing by the Retina
    7. Central Visual Pathways
    8. Perception of Motion, Depth, and Form
    9. Color Vision
    10. Hearing
    11. Sensory Transduction in the Ear
    12. Smell and Taste: The Chemical Senses

  6. Movement
    1. The Organization of Movement
    2. The Motor Unit and Muscle Action
    3. Diseases of the Motor Unit
    4. Spinal Reflexes
    5. Locomotion
    6. Voluntary Movement
    7. The Control of Gaze
    8. The Vestibular System
    9. Posture
    10. The Cerebellum
    11. The Basal Ganglia

  7. Arousal, Emotion, and Behavior Homeostasis
    1. Brain Stem, Reflexive Behavior, and the Cranial Nerves
    2. Brain Stem Modulation of Sensation, Movement, and Consciousness
    3. Seizures and Epilepsy
    4. Sleep and Dreaming
    5. Disorders of Sleep and Wakefulness
    6. The Autonomic Nervous System and the Hypothalamus
    7. Emotional States and Feelings
    8. Motivational and Addictive States

  8. The Development of the Nervous System
    1. The Induction and Patterning of the Nervous System
    2. The Generation and Survival of Nerve Cells
    3. The Guidance of Axons to Their Targets
    4. The Formation and Regeneration of Synapses
    5. Sensory Experience and the Fine-Tuning of Synaptic Connections
    6. Sexual Differentiation of the Nervous System
    7. Aging of the Brain and Dementia of the Alzheimer Type

  9. Language, Thought, Mood, and Learning, and Memory
    1. Language and the Aphasias
    2. Disorders of Thought and Volition: Schizophrenia
    3. Disorders of Mood: Depression, Mania, and Anxiety Disorders
    4. Learning and Memory
    5. Cellular Mechanisms of Learning and the Biological Basis of Individuality
Appendix A - Current Flow in Neurons

Appendix B - Ventricular Organization of Cerebrospinal Fluid: Blood-Brain Barrier, Brain Edema, and Hydrocephalus

Appendix C - Circulation of the Brain

Appendix D - Consciousness and the Neurobiology of the Twenty-First Century


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Principles of Neural Science
Fourth Edition
by Eric R. Kandel

1,414 pages $119.00 + shipping
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