Introducing the most dramatically revised edition of Harrison's ever!

Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips!

Harrison's Principles of Internal Medicine Seventeenth Edition has been massively updated to give you an innovative array of bold new features and content.

Features of Harrison's Principles of Internal Medicine 17th Edition:

• Bonus companion DVD featuring: 37 new “e-chapters”; over 500 brand-new radiological, laboratory, and clinical images, including complete atlases; state-of-the-art video clips; an Image Bank of nearly all the illustrations contained in the parent text, and much more
• Expanded, modernized illustration program with more than 800 brand-new, additional illustrations
• Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues in Medicine: Patient Safety and Health Quality; Health Disparities: Atlas of EKGs; Clinical Management of Obesity: Atlas of Hematology: Atlases of Chest, Neurological, and Cardiovascular Radiology, and much more!
• Brand new, reader-friendly text design optimizes the full-color format
• An expanded focus on global health
• NEW Global Advisory Board comprised of 11 prominent medical experts from Asia, India, Europe, and South America
• Revision of the popular On Line Learning Center

Contents

Part 1: Introduction to Clinical Medicine

1. The Practice of Medicine
2. Global Issues in Medicine
3. Decision-Making in Clinical Medicine
4. Screening and Preventionof Diseases
5. Principles of Clinical Pharmacology
6. Women’s Health
7. Medical Disorders during Pregnancy
8. Medical Evaluation of the Surgical Patient
9. Geriatric Medicine
10. Complementary and Alternative Medicine
11. Palliative and End-of-Life Care

Part 2: Cardinal Manifestations and Presentation of Diseases

12. Pain: Pathophysiology and Management
13. Chest Discomfort
14. Abdominal Pain
15. Headache
16. Back and Neck Pain
17. Fever and Hyperthermia
18. Fever and Rash
19. Fever of Unknown Origin
20. Hypothermia and Frostbite
21. Syncope
22. Dizziness and Vertigo
23. Weakness and Paralysis
24. Gait and Balance Disorders
25. Numbness, Tingling, and Sensory Loss
26. Confusion and Delirium
27. Aphasia, Memory Loss, and Other Focal Cerebral Disorders
28. Sleep Disorders
29. Disorders of the Eye
30. Disorders of Smell, Taste, and Hearing
31. Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections
32. Oral Manifestations of Disease
33. Dyspnea and Pulmonary Edema
34. Cough and Hemoptysis
35. Hypoxia and Cyanosis
36. Edema
37. Palpitations
38. Dysphagia
39. Nausea, Vomiting, and Indigestion
40. Diarrhea and Constipation
41. Weight Loss
42. Gastrointestinal Bleeding
43. Jaundice
44. Abdominal Swelling and Ascites
45. Azotemia and Urinary Abnormalities
46. Fluid and Electrolyte Disturbances
47. Hypercalcemia and Hypocalcemia
48. Acidosis and Alkalosis
49. Sexual Dysfunction
50. Hirsutism and Virilization
51. Menstrual Disorders and Pelvic Pain
52. Approach to the Patient with a Skin Disorder
53. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
54. Skin Manifestations of Internal Disease
55. Immunologically Mediated Skin Diseases
56. Cutaneous Drug Reactions
57. Photosensitivity and Other Reactions to Light
58. Anemia and Polycythemia
59. Bleeding and Thrombosis
60. Enlargement of Lymph Nodes and Spleen
61. Disorders of Granulocytes and Monocytes

Part 3: Genetics and Disease

62. Principles of Human Genetics
63. Chromosome Disorders
64. The Practice of Genetics in Clinical Medicine
65. Gene Therapy in Clinical Medicine

Part 4: Regenerative Medicine

66. Stem Cell Biology
67. Applications of Stem Cell Biology in Clinical Medicine
68. Hematopoietic Stem Cells
69. Tissue Engineering

Part 5: Nutrition

70. Nutritional Requirements and Dietary Assessment
71. Vitamin and Trace Mineral Deficiency and Excess
72. Malnutrition and Nutritional Assessment
73. Enteral and Parenteral Nutrition Therapy
74. Biology of Obesity
75. Evaluation and Management of Obesity
76. Eating Disorders

Part 6: Oncology and Hematology

77. Approach to the Patient with Cancer
78. Prevention and Early Detection of Cancer
79. Cancer Genetics
80. Cancer Cell Biology and Angiogenesis
81. Principles of Cancer Treatment
82. Infections in Patients with Cancer
83. Cancer of the Skin
84. Head and Neck Cancer
85. Neoplasms of the Lung
86. Breast Cancer
87. Gastrointestinal Tract Center
88. Tumors of the Liver and Biliary Tree
89. Pancreatic Cancer
90. Bladder and Renal Cell Carcinomas
91. Benign and Malignant Diseases of the Prostate
92. Testicular Cancer
93. Gynecologic Malignancies
94. Soft Tissue and Bone Sarcomas and Bone Metastases
95. Carcinoma of Unknown Primary
96. Paraneoplastic Syndromes: Endocrinologic/Hematologic
97. Paraneoplastic Neurologic Syndromes
98. Iron Deficiency and Other Hypoproliferative Anemias
99. Disorders of Hemoglobin
100. Megaloblastic Anemia
101. Hemolytic Anemias and Anemias due to Acute Blood Loss
102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
103. Polycythemia Vera and Other Myeloproliferative Diseases
104. Acute and Chronic Myeloid Leukemia
105. Malignancies of Lymphoid Cells
106. Plasma Cell Disorders
107. Transfusion Biology and Therapy
108. Hematopoietic Cell Transplantation
109. Disorders of Platelets and Vessel Wall
110. Coagulation Disorders
111. Thrombosis Venous
112. Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Part 7: Infectious Diseases

113. Introduction to Infectious Diseases: Host-Pathogen Interactions
114. Molecular Mechanisms of Microbial Pathogenesis
115. Approach to the Acutely Ill Infected Febrile Patient
116. Immunization Principles and Vaccine Use
117. Health Advice for International Travel
118. Infective Endocarditis
119. Infections of the Skin, Muscle, and Soft Tissues
120. Osteomyelitis
121. Intraabdominal Infections and Abscesses
122. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
123. Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
124. Sexually Transmitted Infections: Overview and Clinical Approach
125. Health Care-Associated Infections
126. Infections in Transplant Recipients
127. Treatment and Prophylaxis of Bacterial Infections
128. Pneumococcal Infections
129. Staphylococcal Infections
130. Strepococcal and Enterococcal Infections
131. Diphtheria and Other Infections Caused by Corynebacteria and Related Species
132. Infections Caused by Listeria monocytogenes
133. Tetanus
134. Botulism
135. Gas Gangrene and Other Clostridial Infections
136. Meningococcal Infections
137. Gonococcal Infections
138. Moraxella Infections
139. Haemophilus Infections
140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
141. Legionella Infection
142. Pertussis and Other Bordetella Infections
143. Diseases Caused by Gram-Negative Enteric Bacilli
144. Helicobacter Pylori Infections
145. Infections Due to Pseudomonas Species and Related Organisms
146. Salmonellosis
147. Shingellosis
148. Infections Due to Campylobacter and Related Species
149. Cholera and Other Vibrioses
150. Brucellosis
151. Tularemia
152. Plague and Other Yersnia Infections
153. Bartonella Infections, Including Cat-Scratch Disease
154. Donovanosis
155. Nocardiosis
156. Actinomycosis
157. Infections Due to Mixed Anaerobic Organisms
158. Tuberculosis
159. Leprosy (Hansen’s Disease)
160. Nontuberculous Mycobacteria
161. Antimycobacterial Agents
162. Syphilis
163. Endemic Treponematoses
164. Leptospirosis
165. Relapsing Fever
166. Lyme Borreliosis
167. Rickettsial Diseases
168. Infections Due to Mycoplasmas
169. Chlamydial Infections
170. Medical Virology
171. Antiviral Chemotherapy, Excluding Antiretroviral Drugs
172. Herpes Simplex Viruses
173. Varicella-Zoster Virus Infections
174. Epstein-Barr Virus Infections, Including Infectious Mononucleosis
175. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
176. Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus
177. Parvovirus Infections
178. Human Papillomavirus Infections
179. Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
180. Influenza
181. The Human Retroviruses
182. Human Immunodeficiency Virus Disease: AIDS and Related Disorders
183. Viral Gastroenteritis
184. Enterovirus and Reoviruses Infections
185. Measles (Rubeola)
186. Rubella (German Measles)
187. Mumps
188. Rabies and Other Rhabdovirus Infections
189. Infections Caused by Arthropod and Rodent-Borne Viruses
190. Ebola and Marburg Viruses
191. Diagnosis and Treatment of Fungal Infections
192. Histoplasmosis
193. Coccidioidomycosis
194. Blastomycosis
195. Cryptococcosis
196. Candidiasois
197. Aspergillosis
198. Mucormycosis
199. Miscellaneous Mycoses and Algal Infections
200. Pneumocystis Infection
201. Agents Used to Treat Parasitic Infections
202. Ambiasis and Infection with Free-Living Amebas
203. Malaria
204. Babesiosis
205. Leishmaniasis
206. Trypanosomiasis
207. Toxoplasma Infections
208. Protozoal Intestinal Infections and Trichomoniasis
209. Trichinella and Other Tissue Nematodes
210. Intestinal Nematodes
211. Filarial and Related Infections
212. Schistosomiasis and Other Trematode Infections
213. Cestodes

Part 8: Bioterrorism and Clinical Medicine

214. Microbioterrorism
215. Chemical Bioterrorism
216. Radiation Bioterrorism

Part 9: Disorders of Cardiovascular System

217. Basic Biology of the Cardiovascular System
218. Epidemiology of Cardiovascular Disease
219. Approach to the Patient with Possible Cardiovascular Disease
220. Physical Examination of the Cardiovascular System
221. Electrocardiography
222. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
223. Diagnostic Cardiac Catheterization and Angiography
224. Principles of Electrophysiology
225. The Bradyarrhythmias
226. The Tachyarrhythmias
227. Heart Failure and Cor Pulmonale
228. Cardiac Transplantation and Prolonged Assisted Circulation
229. Congenital Heart Disease in the Adult
230. Valvular Heart Disease
231. Cardiomyopathy and Myocarditis
232. Pericardial Disease
233. Tumors and Trauma of the Heart
234. Cardiac Manifestations of Systemic Disease
235. The Pathogenesis, Prevention, and Treatment of Atherosclerosis
236. The Metabolic Syndrome
237. Ischemic Heart Disease
238. Unstable Angina and Non-ST-Elevation Myocardial Infarction
239. ST-Segment Elevation Myocardial Infarction
240. Percutaneous Coronary Intervention
241. Hypertensive Vascular Disease
242. Diseases of the Aorta
243. Vascular Diseases of the Extremities
244. Pulmonary Hypertension

Part 10: Disorders of the Respiratory System

245. Approach to the Patient with Disease of the Respiratory System
246. Disturbances of Respiratory Function
247. Diagnostic Procedures in Respiratory Diseases
248. Asthma
249. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
250. Environmental Lung Disease
251. Pneumonia
252. Bronchiectasis and Lung Abscess
253. Cystic Fibrosis
254. Chronic Obstructive Pulmonary Disease
255. Interstitial Lung Diseases
256. Deep Venous Thrombosis and Pulmonary Thromboembolism
257. Disorders of the Pleura and Mediastinum
258. Disorders of Ventilation
259. Sleep Apnea
260. Lung Transplantation

Part 11: Critical Care Medicine

261. Principles of Critical Care Medicine
262. Acute Respiratory Distress Syndrome
263. Mechanical Ventilatory Support
264. Approach to the Patient with Shock
265. Severe Sepsis and Septic Shock
266. Cardiogenic Shock and Pulmonary Edema
267. Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
268. Coma
269. Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage
270. Oncologic Emergencies

Part 12: Disorders of the Kidney and Urinary Tract

271. Cellular and Molecular Biology of the Kidney
272. Adaptation of the Kidney to Renal Injury
273. Acute Renal Failure
274. Chronic Kidney Disease
275. Dialysis in the Treatment of Renal Failure
276. Transplantation in the Treatment of Renal Failure
277. Glomerular Diseases
278. Polycystic Kidney Disease and Other Inherited Tubular Disorders
279. Tubulointerstitial Diseases of the Kidney
280. Vascular Injury to the Kidney
281. Nephrolithiasis
282. Urinary Tract Infections, Pyelonephritis, and Prostatitis
283. Urinary Tract Obstruction

Part 13: Disorders of the Gastrointestinal System

284. Approach to the Patient with Gastrointestinal Disease
285. Gastrointestinal Endoscopy
286. Diseases of the Esophagus
287. Peptic Ulcer Disease and Related Disorders
288. Disorders of Absorption
289. Inflammatory Bowel Disease
290. Irritable Bowel Syndrome
291. Diverticular Disease and Common Anorectal Disorders
292. Mesenteric Vascular Insufficiency
293. Acute Intestinal Obstruction
294. Acute Appendicitis and Peritonitis
295. Approach to the Patient with Liver Disease
296. Evaluation of Liver Function
297. The Hyperbilirubinemias
298. Acute Viral Hepatitis
299. Toxic and Drug-Induced Hepatitis
300. Chronic Hepatitis
301. Alcoholic Liver Disease
302. Cirrhosis and Its Complications
303. Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
304. Liver Transplantation
305. Diseases of the Gallbladder and Bile Ducts
306. Approach to the Patient with Pancreatic Disease
307. Acute and Chronic Pancreatitis

Part 14: Disorders of the Immune System, Connective Tissue, and Joints

308. Introduction to the Immune System
309. The Major Histocompatability Complex
310. Primary Immune Deficiency Diseases
311. Allergies, Anaphylaxis, and Systemic Mastocytosis
312. Autoimmunity and Autoimmune Diseases
313. Systemic Lupus Erythematosus
314. Rheumatoid Arthritis
315. Acute Rheumatoid Fever
316. Systemic Sclerosis (Scleroderma) and Related Disorders
317. Sjögren’s Syndrome
318. The Spondyloarthritides
319. The Vasculitis Syndromes
320. Beh& ccedil;et’s Syndrome
321. Relapsing Polychondritis
322. Sarcoidosis
323. Familial Mediterranean Fever and Other Hereditary Recurrent Fevers
324. Amyloidosis
325. Approach to Articular and Musculoskeletal Disorders
326. Osteoarthritis
327. Gout and Other Crystal Arthropathies
328. Infectious Arthritis
329. Fibromyalgia
330. Arthritis Associated with Systemic Disease and Other Arthritides
331. Periarticular Disorders of the Extremities

Part 15: Endocrinology and Metabolism

332. 332 Principles of Endocrinology
333. Disorders of the Anterior Pituitary and Hypothalamus
334. Disorders of the Neurohypophysis
335. Disorders of the Thyroid Gland
336. Disorders of the Adrenal Cortex
337. Pheochromocytoma
338. Diabetes Mellitus
339. Hypoglycemia
340. Disorders of the Testes and the Male Reproductive System
341. Disorders of the Ovary and Female Reproductive Tract
342. The Menopause Transition and Postmenopausal Hormone Therapy
343. Disorders of Sex Development
344. Endocrine Tumors of the Gastrointestinal Tract and Pancreas
345. Disorders Affecting Multiple Endocrine Neoplasia Syndromes
346. Bone and Mineral Metabolism in Health and Disease
347. Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders
348. Osteoporosis
349. Paget Disease and Other Dysplasias of Bone
350. Disorders of Lipoprotein Metabolism
351. Hemochromatosis
352. The Porphyrias
353. Disorders of Purine and Pyrimidine Metabolism
354. Wilson Disease
355. Lysosomal Storage Disease
356. Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
357. Heritable Disorders of Connective Tissue
358. Inherited Disoders of Amino Acid Metabolism in Adults
359. Inherited Defects of Membrane Transport

Part 16: Neurologic Disorders

360. Mechanisms of Neurologic Disorders
361. Approach to the Patient with Neurologic Disease
362. Neuroimaging in Neurologic Disorders
363. Seizures and Epilepsy
364. Cerebrovascular Diseases
365. Dementia
366. Parkinson’s Disease and Other Extrapyramidal Disorders
367. Hyperkinetic Movement Disorders
368. Ataxic Disorders
369. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
370. Disorders of the Autonomic Nervous System
371. Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
372. Diseases of the Spinal Cord
373. Concussion and Other Head Injuries
374. Primary and Metastatic Tumors of the Nervous System
375. Multiple Sclerosis and Other Demyelinating Diseases
376. Meningitis, Encephalitis, Brain Abscess,and Empyema
377. Chronic and Recurrent Meningitis
378. Prion Diseases
379. Peripheral Neuropathy
380. Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
381. Mysathenia Gravis and Other Diseases of the Neuromuscular Junction
382. An Approach to Muscular Dystrophy and Other Muscle Diseases
383. Polymyositis, Dermatomyositis, and Inclusion Body Myositis
384. Chronic Fatigue Syndrome
385. Biology of Psychiatric Disorders
386. Mental Disoders
387. Alcohol and Alcoholism
388. Opioid Drug Abuse and Dependence
389. Cocaine and Other Commonly Abused Drugs
390. Nicotine Addiction

Part 17: Poisoning, Drug Overdose, and Envenomation

391. Disorders Caused by Reptile Bites and Marine Animal Exposures

Appendix
Index

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