Process Analytical Techology is to provide a starting point for implementing process analytical chemistry tools in process monitoring applications or as part of a total quality management system.

Process Analytical Techology covers:

• key spectroscopic tools
• their applications in the pharmaceutical and chemical industries and basic chemometrics
• the novice can quickly develop a sound understanding of the most practical technologies and applications

Contents

1. Process Analytical Chemistry: Introduction and Historical Perspective

• Historical Perspective
• Early Instrument Development
• Sampling Systems

2. Implementation of Process Analytical Technologies

• Introduction to Implementation of Process Analytical Technologies in the Industrial Setting
• Generalized Process Analytics Work Process
• Differences Between Implementation in Chemical and Pharmaceutical Industries

3. Near-Infrared Spectroscopy for Process Analytical Chemistry: Theory, Technology and Implementation

• Theory of Near-Infrared Spectroscopy
• Analyser Technologies in the Near-Infrared
• The Sampling Interface

4. Infrared Spectroscopy for Processs Analytical Applications

• Basic IR Spectroscopy
• Instrumentation Design and Technology
• Process IR Instrumentation
• Applications of Process IR Analyzers
• Process IR Analyzers: A Review
• Trends and Directions

5. Process Raman Spectroscopy

• How Raman Spectroscopy Works
• When Raman Spectroscopy Works Well and When it does not
• What are the Secial Design Issues for Process Raman Instruments?
• Where Raman Spectroscopy is Being Used
• What is the Current State of Raman Spectroscopy?

6. UV-Vis for On-Line Analysis

• Theory
• Instrumentation
• Sample Interface
• A Complete Process Analyzer
• Applications

7. Near-Infrared Chemical Imaging as a Process Analytical Tool

• The Process Analytical Technology Initiative
• The Role of Near-Infrared Chemical Imaging in the Pharmaceutical Industry
• The Development of Imaging Spectroscopy
• Chemical Imaging Principles
• PAT Applications
• Processing Case Study One: Estimating 'Abundance' of Sample Components
• Processing Case Study Two: Determining Blend Homogeneity Through Statistical Analysis

8. Chemometrics in Process Analytical Chemistry

• The Building Blocks of Chemometrics
• Quantitative Model Building
• Outliers
• Qualitative Model Building
• Exploratory Analysis
• The 'Calibration Sampling Paradox' of Process Analytical Chemistry
• Sample and Variable Selection in Chemometrics
• Calibration Transfer
• Non-Technical Issues

9. On-Line Applications in the Pharmaceutical Industry

• Reaction Monitoring and Control
• Crystallization Monitoring and Control
• Drying
• Milling
• Cleaning Validation
• Solid Dosage form Manufacture
• Granulation and Blending of API and Excipients
• Detection of Drug Polymorphism
• Spectroscopic Techniques for Tablets

10. Use of Near-Infrared Spectroscopy for Off-Line Measurements in the Pharmaceutical Industry

• Qualitative Analysis
• Quantitative Analysis
• Method Validation
• Matching Models
• Pharmaceutical Applications

11. Applications of Near-Infrared Spectroscopy in the Chemical Industry

• Successful Process Analyzer Implementation
• Example Applications

12. Future Trends in Process Analytical Chemistry

• Sensor Development
• New Types of PAC Hardware Tools
• Data Communication
• Data Handling
• New Application Areas of PAC

Index

click here to see books • videos • cd-roms of related interest