Analytical Technology Book from C.H.I.P.S.

Process Analytical Techology
Edited by Katherine A. Bakeev

Process Analytical Techology is to provide a starting point for implementing process analytical chemistry tools in process monitoring applications or as part of a total quality management system.

Process Analytical Techology covers:

  • key spectroscopic tools
  • their applications in the pharmaceutical and chemical industries and basic chemometrics
  • the novice can quickly develop a sound understanding of the most practical technologies and applications


1. Process Analytical Chemistry: Introduction and Historical Perspective

  • Historical Perspective
  • Early Instrument Development
  • Sampling Systems

2. Implementation of Process Analytical Technologies

  • Introduction to Implementation of Process Analytical Technologies in the Industrial Setting
  • Generalized Process Analytics Work Process
  • Differences Between Implementation in Chemical and Pharmaceutical Industries

3. Near-Infrared Spectroscopy for Process Analytical Chemistry: Theory, Technology and Implementation

  • Theory of Near-Infrared Spectroscopy
  • Analyser Technologies in the Near-Infrared
  • The Sampling Interface

4. Infrared Spectroscopy for Processs Analytical Applications

  • Basic IR Spectroscopy
  • Instrumentation Design and Technology
  • Process IR Instrumentation
  • Applications of Process IR Analyzers
  • Process IR Analyzers: A Review
  • Trends and Directions

5. Process Raman Spectroscopy

  • How Raman Spectroscopy Works
  • When Raman Spectroscopy Works Well and When it does not
  • What are the Secial Design Issues for Process Raman Instruments?
  • Where Raman Spectroscopy is Being Used
  • What is the Current State of Raman Spectroscopy?

6. UV-Vis for On-Line Analysis

  • Theory
  • Instrumentation
  • Sample Interface
  • A Complete Process Analyzer
  • Applications

7. Near-Infrared Chemical Imaging as a Process Analytical Tool

  • The Process Analytical Technology Initiative
  • The Role of Near-Infrared Chemical Imaging in the Pharmaceutical Industry
  • The Development of Imaging Spectroscopy
  • Chemical Imaging Principles
  • PAT Applications
  • Processing Case Study One: Estimating 'Abundance' of Sample Components
  • Processing Case Study Two: Determining Blend Homogeneity Through Statistical Analysis

8. Chemometrics in Process Analytical Chemistry

  • The Building Blocks of Chemometrics
  • Quantitative Model Building
  • Outliers
  • Qualitative Model Building
  • Exploratory Analysis
  • The 'Calibration Sampling Paradox' of Process Analytical Chemistry
  • Sample and Variable Selection in Chemometrics
  • Calibration Transfer
  • Non-Technical Issues

9. On-Line Applications in the Pharmaceutical Industry

  • Reaction Monitoring and Control
  • Crystallization Monitoring and Control
  • Drying
  • Milling
  • Cleaning Validation
  • Solid Dosage form Manufacture
  • Granulation and Blending of API and Excipients
  • Detection of Drug Polymorphism
  • Spectroscopic Techniques for Tablets

10. Use of Near-Infrared Spectroscopy for Off-Line Measurements in the Pharmaceutical Industry

  • Qualitative Analysis
  • Quantitative Analysis
  • Method Validation
  • Matching Models
  • Pharmaceutical Applications

11. Applications of Near-Infrared Spectroscopy in the Chemical Industry

  • Successful Process Analyzer Implementation
  • Example Applications

12. Future Trends in Process Analytical Chemistry

  • Sensor Development
  • New Types of PAC Hardware Tools
  • Data Communication
  • Data Handling
  • New Application Areas of PAC


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Process Analytical Technology
Edited by Katherine A. Bakeev
2005 451 pages $229.00 + shipping
Texas residents please add 6.75 % sales tax

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