Protein Lipid Interactions covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle.

Features:

• Examines the relevant hermodynamic and structural issues from a basic science perspective
• Discuss biochemical and cell biological processes
• Covers physical principles as well as mechanisms of membrane fusion and fission

Contents

How Lipids Share Proteins

• Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure
• Folding and Stability of Monomeric beta-Barrel Membrane Proteins
• A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding
• Post-Integration Misassembly of Membrane Proteins and Disease

How Proteins Share Lipids

• A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins
• Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance

Membrane Penetration by Toxins

• Lipid Interactions of a-Helical Protein Toxins
• Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins
• Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides

Mechanisms of Membrane Fusion

• Cell Fusion in Development and Disease
• Molecular Mechanisms of Intracellular Membrane Fusion
• Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion

Cholesterol, Lipid Rafts, and Protein Sorting

• Protein-Lipid Interactions in the Formation of Raft Microdomains in Biololgical Membranes
• Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes

Targeting of Extrinsic Membrane Protein Modules to Membranes and Signal Transduction

• In vitro and Cellular Membrane-binding Mechanisms of Membrane-targeting Domains
• Structure and Interactions of C2 Domains at Membrane Surfaces
• Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains

Index

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