Process Scale Purification of Antibodies offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification.

The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.

Contents

1. Downstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities
2. The Development of Antibody Purification Technologies
3. Harvest and Recovery of Monoclonal Antibodies: Cell Removal and Clarification
4. Protein A-Based Affinity Chromatography
5. Purification of Human Monoclonal Antibodies: Non-Protein A Strategies
6. Purification of Monoclonal Antibodies by Mixed Mode Chromatography
7. Integrated Polishing Steps for Monoclonal Antibody Purification
8. Orthogonal Virus Clearance Applications in Monoclonal Antibody Production
9. Development of A Platform Process for the Purification of Therapeutic Monoclonal Antibodies
10. Advances in Technology and Process Development for Industrial Scale Monoclonal Antibody Purification
11. Continuous Chromatography for the Purification of Monoclonal Antibodies
12. Process Economic Drivers in Industrial Monoclonal Antibody Manufacture
13. Design and Optimization of Manufacturing
14. Alternatives to Packed-Bed Chromatography for Antibody Extraction and Purification
15. Process-Scale Precipitation of Impurities in Mammalian Cell Culture Broth
16. Charged Ultrafiltration and Microfiltration Membranes in Antibody Purification
17. Downstream Processing of Monoclonal Antibody Fragments
18. Purification of Antibodies Other Than IgG - The Case of IgM and IgA
19. Purification of Antibodies From Transgenic Plants
20. Antibody Purification: Drivers of Change

Index

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