Medical Book from C.H.I.P.S.

Prostate Cancer
Principles and Practice
edited by Roger S. Kirby

Prostate Cancer covers the etiology, pathophysiology, diagnosis, management and treatment of early and advanced prostate cancer.


  • The pathology and etiology of prostate cancer
  • Molecular mechanisms of prostate carcinogenesis
  • Clinical diagnosis and staging of prostate cancer
  • Treatment of early stage prostate cancer
  • Treatment of locally advanced and metastatic prostate cancer



  1. Prostate cancer: A historical introduction
  2. Genetic epidemiology
  3. Risk factors for prostate cancer: diet and lifestyle studies
  4. Molecular epidemiology of prostate cancer
  5. Applications of gene array technology to prostate cancer
  6. Topographic anatomy of the prostate, seminal vesicles, vas deferens, and ejaculatory ducts
  7. Prostate physiology and function
  8. Neuroanatomy and neuroregulation
  9. Androgens and the androgen receptor in normal prostate
  10. Regulation of prostate growth

Pathology of Prostate Cancer

  1. Histopathology of prostate cancer and pathologic staging
  2. Pre-malignant and atypical lesions
  3. Pathologic characteristics of soft tissue and osseous metastases
  4. Non-adenocarcinomatous neoplasms of the prostate
  5. Neuroendocrine differentiation in prostate cancer
  6. New concepts in the molecular pathology of prostate cancer
  7. Cytogenetics and molecular heterogeneitity

Etiology of Prostate Cancer

  1. Concepts in etiology of prostate cancer
  2. Diet and obesity in prostate carcinogenesis
  3. Chemoprevention of prostate cancer: Concepts and evidence
  4. Molecular aspects of chemoprevention of prostate cancer
  5. Androgen replacement in the aging male and prostate cancer
  6. Vitamin D, retinoids, and prostate cancer

Molecular Mechanisms of Prostate Carcinogenesis

  1. Mechanisms of prostate cancer progression
  2. Case control and linkage studies in familial and hereditary prostate cancer
  3. Prostate Cancer Stem Cells
  4. Rationale for molecular biomarkers of prostate cancer
  5. Molecular biology of serum biomarkers for prostate cancer
  6. Molecular biology of tissue biomarkers for prostate cancer
  7. Biologic response modifiers and prostate cancer
  8. Cell adhesion and prostate cancer
  9. Apoptosis and prostate cancer
  10. Cellular proliferation and senescence in prostate cancer
  11. Angiogenesis and prostate cancer
  12. Endothelin and prostate cancer
  13. Mechanisms of androgen resistance
  14. Knockout models of prostate carcinogenesis
  15. Molecular mechanisms of prostate cancer metastases
  16. Molecular concepts of emerging strategies for prostate cancer treatment

Clinical Diagnosis and Staging of Prostate Cancer

  1. New concepts in the early detection of prostate cancer
  2. Screening for prostate cancer: The ERSPC Study
  3. Screening for prostate cancer and its effect on mortality: The TYROL Study Endothelin and prostate cancer
  4. Lessons from the Prostate Cancer Awareness Week Program and PLCO Study
  5. Clinical staging of prostate cancer: An overview
  6. TNM and IUCC staging of prostate cancer
  7. PSA: Practical applications and future prospects
  8. Clinical applications of PSA isoforms
  9. Radiographic anatomy of the prostate
  10. Transrectal and transperineal ultrasound-guided prostate biopsy
  11. Multivariate models for decreasing unnecessary biopsies
  12. MR Imaging (MRI) and MR Spectroscopic Imaging (MRSI) in the diagnosis and staging of prostate cancer.
  13. Radioimmunoscintography for imaging prostate cancer
  14. Clinical applications of immunoscintigraphy for prostate cancer
  15. Future directions in the imaging of prostate cancer
  16. Local therapy for prostate-specific antigen recurrence after definitive treatment.
  17. Multivariate models for predicting pathological stage
  18. Multivariate models for predicting biochemical recurrence after definitive local therapy
  19. Coping with a diagnosis of prostate cancer: A patient's perspective
  20. Clinical interpretation of prostate cancer biopsy reports
  21. Urine-based diagnostic tests for prostate
  22. Diagnostic tests for prostate cancer: Future directions

Treatment of Early Stage Prostate Cancer

  1. Choosing prostate cancer treatment: The clinician as patient
  2. The role of the primary care professional in the care of the prostate cancer patient
  3. Natural history and expectant management of prostate cancer
  4. Clinical trials comparing expectant management to definitive treatment of prostate cancer (PIVOT, Holmberg, PROTECT, etc.)
  5. Complimentary and alternative medicine in the prevention and treatment of prostate cancer
  6. Mortality trends in prostate cancer
  7. Preservation of sexual function in prostate cancer treatment
  8. Quality of life instruments for prostate cancer
  9. Comparison of treatment modalities for prostate cancer by quality of life instruments
  10. Decision tools in patient selection for radical prostatectomy
  11. Anatomical considerations of radical prosptatectomy
  12. Radical retropubic prostatectomy
  13. Radical retropubic prostatectomy: contemporary modifications
  14. The role of lymph node dissection in radical prostatectomy
  15. Management of biochemical recurrence following radical prostatectomy
  16. Radical perineal prostatectomy
  17. Laparoscopic and robotic radical prostatectomy
  18. Vattikuti Institute Prostatectomy
  19. Initial management of high risk early stage prostate cancer: surgery
  20. Management of short and long term complications of radical prostatectomy
  21. External beam radiotherapy for the treatment of prostate cancer
  22. Brachytherapy for the treatment of prostate cancer
  23. HDR monotherapy for prostate cancer
  24. Magnetic resonance image-guided partial prostatic irradiation in select patients with clinically localized adenocarcinoma of the prostate
  25. Hyperthermia for treatment of localized prostate cancer
  26. Initial management of high risk early stage prostate cancer: radiation
  27. Management of biochemical recurrence following radiation therapy
  28. Cryotherapy as primary therapy for prostate cancer
  29. Cryotherapy as salvage therapy for prostate cancer
  30. Androgen deprivation for the treatment of prostate cancer: General principles
  31. Neoadjuvant and adjuvant hormonal therapies for prostate cancer: data review and patient perspectives
  32. Controversies in hormone treatment for prostate cancer
  33. Androgen deprivation for prostate cancer: Future directions
  34. Rehabilitation of urinary continence following definitive treatment of local prostate cancer
  35. Rehabilitation of sexual function following definitive treatment of local prostate cancer
  36. The limitations ofevidence based comparisons of treatment for localized prostate cancer

Treatment of Locally Advanced and Metastatic Prostate Cancer

  1. Hormone therapy for prostate cancer: Optimization and timing
  2. Intermittent hormone therapy for prostate cancer
  3. Anti-androgen withdrawal syndrome: Identification and treatment
  4. Chemotherapy for advanced prostate cancer
  5. Radiotherapy for the treatment of locally advanced and metastatic prostate cancer
  6. Radionucleotides for the treatment of metastatic prostate cancer
  7. Use of bis-phosphonates in the management of osseous metastases
  8. Treatment of non-adenocarcinomatous and small cell neoplasms of the prostate
  9. Multi-modal therapy for advanced prostate cancer
  10. Management of complications of advanced prostate cancer
  11. Principles of palliative care and psychosocial support of the metastatic prostate cancer patient
  12. Future directions for treatment of advanced prostate cancer: Gene therapy and other novel modalities
  13. Prostate cancer and the media: Raising public awareness


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Prostate Cancer
Principles and Practice
edited by Roger S. Kirby

2006 1104 pages $738.95 + shipping
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