Proteomics for Biological Discovery provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics.

Features:

• Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications
• Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications
• Discusses higher level integrative aspects, including technical challenges and applications for drug discovery
• Accessible to the novice while providing experienced investigators essential information

Contents

Foundations of Proteomics

• Mass Spectrometry: The Foundations of Proteomics
• Proteomic Analysis by Two-Dimensional Polycrylamide Gel Electrophoresis
• Isotope Labeling in Quantitative Proteomics
• Proteome Analysis of Post-Translational Modifications
• Technologies for Large Scale Proteomic Tandem Mass Spectrometry
• Protein Fractionation Methods for Proteomics

Functional Proteomics

• Protein Localization by Cell Imaging
• Characterization of Functional Protein Complexes
• Structural Proteomics by NMR

Novel Approaches in Proteomics

• Protein Microarrays
• Microfluidics
• 12. Single Cell Proteomics
• Diagnostic Proteomics
• Automation in Proteomics
• Bioinformatics

Index

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