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Pharmaceutical Drug Design Book from C.H.I.P.S.

Protein Crystallography in Drug Discovery

edited by R.E. Babine
and S.S. Abdel-Meguid


In Protein Crystallography in Drug Discovery, researchers from academia and from leading pharmaceutical companies present valuable first-hand information on how to obtain the desired protein structures and how to exploit crystallographic data for the drug discovery process.

Covers:

  • Crystallography of important target classes such as kinases and proteases
  • Structure-based design of protease inhibitors
  • Structure-based design of kinase inhibitors
  • The ribosome and the proteasome as drug targets
  • Recent methodological advances in high-throughput crystallography and microcrystallization

Protein Crystallography in Drug Discovery is an indispensable companion for crystallographers involved in protein structure determination as well as drug developers following the structure-based approach.

Contents

  1. Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes
  2. Kinases
  3. The Proteasome as a Drug Target
  4. Antibiotics and the Ribosome
  5. Structure-Based Design of Cathepsin K Inhibitors
  6. Structure-Based Design of Potent and Selective Cdk4 Inhibitors
  7. Crystallization and Analysis of Serine Proteases with Ecotin
  8. X-ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs
  9. Engineering Proteins to Promote Crystallization
  10. High-throughput Crystallography
  11. Micro-Crystallization

Subject Index

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Protein Crystallography in Drug Discovery
edited by R.E. Babine and S.S. Abdel-Meguid
262 pages $174.00 + shipping

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