Protein Degradation discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology.

This handy reference provides up-to-date information on the action of the ubiquitin system in as diverse functions as:

• organelle biogenesis
• muscle development
• the cellular response to hypoxia
• extraction of proteins from the endoplasmic reticulum for degradation
• the regulation of plant development

Contents

Ubiquitin: A New Player in the Peroxisome Field

• Matrix Protein Import into Peroxisomes is Mediated by Cycling Receptors
• Pex5p is Monoubiquitinated in Wild-type Cells, but Polyubiquitinated in Late-acting pex Mutants
• Ubiquitination of Pex18p
• Role for the RING Finger and AAA Peroxins in Pex5p Ubiquitination and Recycling
• Pex5p Monoubiquitination: A Role in Receptor Recycling

The Ubiquitin Proteasome System and Muscle Development

• Muscle Histology
• UPS and Developing Muscle
• UPS and Organizing Muscle
• UPS and Muscle Destruction or Degeneration

The COP9 Signalosome: Structural and Biochemical Conservation and Its Roles in the Regulation of Plant Development

• The Plant COP9 Signalosome
• CSN Involvement in the Ubiquitin–Proteasome Pathway
• Plant CSN Biochemical Activities
• CSN Functions in Plant Development

Ubiquitin and Protein Sorting to the Lysosome

• Identification of Ubiquitin as an Endosomal Sorting Signal
• Ubiquitin-mediated Sorting at the Endosome: The MVB Sorting Machinery
• Ubiquitin Ligases and Endosomal Sorting
• Endosomal DUBs
• Polyubiquitin Linkages and Endocytosis

ISG15-dependent Regulation

• The Discovery of ISG15
• Structure and Properties of the ISG15 Protein
• The ISG15 Conjugation Pathway
• Regulation of Intracellular ISG15 Pools
• Functional Roles for ISG15

The Role of the Ubiquitin–Proteasome Pathway in the Regulation of the Cellular Hypoxia Response

• Players in the Hypoxia-response Signalling Pathway
• pVHL-dependent Degradation of HIF-1a
• Siah-dependent Regulation of PHD
• Other Examples of Altered Ubiquitination During Hypoxia
• Ischemia Model
• Regulation of the Ubiquitin System in Hypoxia

p97 and Ubiquitin: A Complex Story

• Interactions of Ubiquitin, p97 and Adaptors
• The Cellular Roles of p97 and Ubiquitin
• The Action of p97
• When Things Go Wrong: p97 in Disease

Cdc48 (p97) and Its Cofactors

• Cdc48 Cofactors
• Cellular Functions

Deubiquitinating Enzymes, Cell Proliferation, and Cancer

• DUBs, Oncogenes, and Cell Transformation

Index

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