Pharmaceutical Book from C.H.I.P.S.

Protein Degradation Volume 2
The Ubiquitin Proteasome System
edited by R. John Mayer

Protein Degradation Volume 2 discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.


  • Compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway
  • Includes latest results on novel members of the ubiquitin superfamily and their role in cellular regulation


Molecular Chaperones and the Ubiquitin–Proteasome System

  • A Biomedical Perspective
  • Molecular Chaperones: Mode of Action and Cellular Functions
  • Chaperones: Central Players During Protein Quality Control
  • Chaperones and Protein Degradation
  • The CHIP Ubiquitin Ligase: A Link Between Folding and Degradation Systems
  • Other Proteins That May Influence the Balance Between Chaperoneassisted Folding and Degradation

Molecular Dissection of Autophagy in the Yeast Saccharomyces cerevisiae

  • Vacuoles as a Lytic Compartment in Yeast
  • Discovery of Autophagy in Yeast
  • Genetic Dissection of Autophagy
  • Characterization of Autophagy-defective Mutants
  • Cloning of ATG Genes
  • Further Genes Required for Autophagy
  • Selectivity of Proteins Degraded
  • Induction of Autophagy
  • Membrane Dynamics During Autophagy
  • Monitoring Methods of Autophagy in the Yeast S. cerevisiae
  • Function of Atg Proteins
  • Site of Atg Protein Functioning: The Pre-autophagosomal Structure
  • Atg Proteins in Higher Eukaryotes
  • Atg Proteins as Markers for Autophagy in Mammalian Cells
  • Physiological Role of Autophagy in Multicellular Organisms

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

  • The Proteasome as an Essential Component of Intracellular Proteolysis
  • Proteasome Structure, Function, and Localization
  • Proteasome Inhibitors as Tools to Study Proteasome Function
  • Assessing the Biological Role of the Proteasome With Inhibitors and Probes
  • Proteasome-associated Components: The Role of N-glycanase
  • A Link Between Proteasomal Proteolysis and Deubiquitination

MEKK1: Dual Function as a Protein Kinase and a Ubiquitin Protein Ligase

  • Types of Protein Kinases
  • Functions of Protein Kinases

Proteasome Activators

  • 11S Activators: Sequence and Structure
  • PA26–Proteasome Complex Structures
  • Biological Roles of 11S Activators
  • PA200/Blm10p

The Proteasome Portal and Regulation of Proteolysis

  • The Importance of Channel Gating
  • A Porthole into the Proteasome
  • Facilitating Traffic Through the Gated Channel

Ubiquity and Diversity of the Proteasome System

  • Catalytic Machine
  • Regulatory Factors
  • Proteasome Assembly

Proteasome-Interacting Proteins

  • Regulators of the Holoenzyme and Chaperones Involved in Assembly of the Proteasome
  • Enzymes Controlling Ubiquitination and Deubiquitination
  • Shuttling Proteins: Rpn10/Pus1 and UBA-UBL Proteins
  • Other UBL-Containing Proteins
  • VCP/p97/cdc48
  • Proteasome Interactions with Transcription, Translation and DNA Repair

Structural Studies of Large, Self-compartmentalizing Proteases

  • Self-compartmentalization: An Effective Way to Control Proteolysis
  • ATP-dependent Proteases: The Initial Steps in the Proteolytic Pathway
  • Beyond the Proteasome: ATP-independent Processing of Oligopeptides Released by the Proteasome

What the Archaeal PAN–Proteasome Complex and Bacterial ATP-dependent Proteases Can Teach Us About the 26S Proteasome

  • Archaeal 20S Proteasomes
  • PAN the Archaeal Homologue of the 19S Complex
  • VAT, a Potential Regulator of Proteasome Function
  • The Use of PAN to Understand the Energy Requirement for Proteolysis
  • Direction of Substrate Translocation
  • Degradation of Polyglutamine-containing Proteins
  • Eubacterial ATP-dependent Proteases
  • How AAA ATPases Use ATP to Catalyze Proteolysis

Biochemical Functions of Ubiquitin and Ubiquitin-like Protein Conjugation

  • Ubls: A Typical Modification Cycle by an Atypical Set of Modifiers
  • Origins of the Ubiquitin System
  • Ubiquitin-binding Domains and Ubiquitin Receptors in the Proteasome Pathway
  • Ubiquitin-binding Domains and Membrane Protein Trafficking
  • Sumoylation and SUMO-binding Motifs
  • General Biochemical Functions of Protein–Protein Conjugation


click here to see books • videos • cd-roms of related interest


Protein Degradation Volume 2
The Ubiquitin Proteasome System
edited by R. John Mayer

2006 • 300 pages • $199.00 + shipping
Texas residents please add 6.75 % sales tax

Go to Top of Page

copyright © 1997-2009 Culinary and Hospitality Industry Publications Services