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Proteomics in Drug Research
edited by Michael Hamacher

Proteomics in Drug Research coverage of a wide range of technologies and areas of application.


  • Includes proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ
  • Details bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics
  • Provides a necessary perspective on current trends and developments


Administrative Optimization of Proteomics Networks for Drug Development

  • Tasks and Aims of Administration.
  • Networking.
  • Evaluation of Biomarkers.
  • A Network for Proteomics in Drug Development.
  • Realization of Administrative Networking: the Brain Proteome Projects

Proteomic Data Standardization, Deposition and Exchange

  • Protein Analysis Tools.
  • Data Storage and Retrieval.
  • The Proteome Standards Initiative.
  • General Proteomics Standards (GPS).
  • Mass Spectrometry.
  • Molecular Interactions

Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research

  • Difference Gel Electrophoresis: Next Generation of Protein Detection in 2-DE

Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches

  • Ionization Principles.
  • Mass Spectrometric Instrumentation.
  • Protein Identification Strategies.
  • Quantitative Mass Spectrometry for Comparative and Functional Proteomics.
  • Metabolic Labeling Approaches.
  • Chemical Labeling Approaches.
  • Quantitative MS for Deciphering Protein–Protein Interactions

Multidimensional Column Liquid Chromatography (LC) in Proteomics – Where Are We Now

  • Why Do We Need MD-LC/MS Methods?
  • Basic Aspects of Developing a MD-LC/MS Method.
  • Applications of MD-LC Separation in Proteomics – a Brief Survey.
  • Sample Clean-Up: Ways to Overcome the “Bottleneck” in Proteome Analysis

Peptidomics Technologies and Applications in Drug Research

  • Peptides in Drug Research.
  • Development of Peptidomics Technologies.
  • Applications of Differential Display Peptidomics.
  • Outlook

Protein Biochips in the Proteomic Field

  • Technological Aspects.
  • Applications of Protein Biochips.
  • Contribution to Pharmaceutical Research and Development

Current Developments for the In Vitro Characterization of Protein Interactions

  • The Model System: cAMP-Dependent Protein Kinase.
  • Real-time Monitoring of Interactions Using SPR Biosensors.
  • ITC in Drug Design.
  • Fluorescence Polarization, a Tool for High-Throughput Screening.
  • AlphaScreen as a Pharmaceutical Screening Tool

Molecular Networks in Morphologically Intact Cells and Tissue–Challenge for Biology and Drug Development

  • A Metaphor of the Cell.
  • Mapping Molecular Networks as Patterns: Theoretical Considerations.
  • Imaging Cycler Robots.
  • Formalization of Network Motifs as Geometric Objects.
  • Gain of Functional Information: Perspectives for Drug Development

From Target to Lead Synthesis

  • Materials and Methods

Differential Phosphoproteome Analysis in Medical Research

  • Phosphoproteomics of Human Platelets.
  • Identification of cAMP- and cGMP-Dependent Protein Kinase Substrates in Human Platelets.
  • Identification of a New Therapeutic Target for Anti-Inflammatory Therapy by Analyzing Differences in the Phosphoproteome of Wild Type and Knock Out Mice.

Biomarker Discovery in Renal Cell Carcinoma Applying Proteome-Based Studies in Combination with Serology

  • Rational Approaches Used for Biomarker Discovery.
  • Advantages of Different Proteome-Based Technologies for the Identification of Biomarkers.
  • Type of Biomarker.
  • Proteome Analysis of Renal Cell Carcinoma Cell Lines and Biopsies.
  • Validation of Differentially Expressed Proteins

Studies of Drug Resistance Using Organelle Proteomics

  • Objectives and Experimental Design.
  • Changes in Plasma Membrane and Nuclear Proteins in MCF-7 Cells Resistant to Mitoxantrone

Clinical Neuroproteomics of Human Body Fluids: CSF and Blood Assays for Early and Differential Diagnosis of Dementia

  • Neurochemical Markers of Alzheimer’s Disease

Proteomics in Alzheimer’s Disease

  • Proteomic Analysis.
  • Proteins with Deranged Levels and Modifications in AD.
  • Limitations

Cardiac Proteomics

  • Heart Proteomics.
  • Vessel Proteomics

Innovation Processes

  • Innovation Process Criteria.
  • The Concept.
  • Market Attractiveness.
  • Competitive Market Position.
  • Competitive Technology Position.
  • Strengthen the Fit.
  • Reward.
  • Risk.
  • Innovation Process Deliverables for each Stage.
  • Stage Gate-Like Process


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Proteomics in Drug Research
edited by Michael Hamacher
2006 • 384 pages • $189.00 + shipping
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