The Proteasome in Neurodegeneration provides an in depth analysis and provocative discussion of what role normal and aberrant proteasome function plays in regulating various aspects of brain homeostasis.

The Proteasome in Neurodegeneration contains up-to-date reviews on different aspects of hte ubliquitin proteasome system and its involvement in several neurodegenerative diseases.

The Proteasome in Neurodegeneration provides information on the basics of the ubliquitin proteasome system, but mainly describes a number of aspects of involvement of this system in neurodegeneration.

Contents

Basic Aspects of Protein Degradation Through the Ubliquitin Proteasome System

1. Yeast Proteasome Structure and Biogenesis
2. Ubliquitin-Proteasome Function in the Central Nervous System

Protein Aggregation, Inclusion Formation and Ups Function

3. Protein Aggregation and the Ups: A Two Way Street
4. Impact of Inclusion Formation on Cell Survival
5. Inclusion Formation and Dissolution Following Proteasomal Inhibition in Neuronal Cells

Oxidative Stress and Ups Function

6. The Proteasome: Both a Source and a Target of Oxidative Stress?
7. Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction

Proteasome and Neuronal Cell and Survival

8. Role of the Ubiquitin Proteasome System During Neural Cell Death
9. Mechanisms of Neural Death Induced by Proteasomal Inhibition

Models of Dysfunction of the UPS and the Proteasome

10. Pharmacological and Molecular Models of Proteasomal Dysfunction
11. The GAD Mouse: A Window into UPS-Related Neurodegeneration and the Function of the Deubiquitinating Enzyme UCH-L1

The UPS in Neurodegenerative Diseases and Aging

12. Parkinson's Disease and Related Disorders
13. Ubiquitination by Parking-Inplications in Parkinson's Disease
14. Huntington's Disease
15. Frameshift Ubiquitin Mutant in Alzheimer' Disease and Other Neurodegenerative Disorders
16. Motor Neuron Disease
17. The Paradoxical Role of Proteasomes in Prion Diseases
18. Aging and the Proteasome

Index

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