Protein Synthesis and Ribosome Structure:
Translating the Genome

edited by K.H. Nierhaus
and D.N. Wilson

Based on more than 30 years of ribosome research and incorporating the most recent structural evidence, this book presents a uniform picture of the largest enzyme complex found in living cells, shedding light on many decades-old questions in molecular biology.

Coverage includes:

• Structure of the Ribosome
• Ribosome Assembly
• tRNA and Synthetases
• mRNA Degradation
• Initiation and Elongation
• Termination and Ribosome Recycling
• Regulation of Ribosome Biosynthesis
• Inhibition of the Translational Apparatus by Antibiotics

A premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Contents

1. History of Protein Biosynthesis and Ribosome Research
2. Structure of the Ribosome
3. Ribosome Assembly
4. tRNA and Synthetases
5. mRNA Decay and RNA-degrading Machines in Prokaryotes and Eukaryotes
6. tRNA Locations on the Ribosome
7. Initiation of Protein Synthesis
8. The Elongation Cycle
9. Termination and Ribosome Recycling
10. The Mechanism of Recoding in Pro- and Eukaryotes
11. Regulation of Ribosome Biosynthesis in Escherichia coli
12. Antibiotics and the Inhibition of Ribosome Function
13. The Work of Chaperones

Index

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