Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available.

Brand new chapters cover:

• the measurement of cell kinetics
• obstetric transfusion practice
• cord blood
• transfusion alternatives
• regenerative medicine

Produced jointly with AABB, the world's leading association in the fields of blood banking and transfusion medicine, Principles of Transfusion Medicine now has two companion CD-ROMs-one containing interactive case studies and one containing PDFs of all 66 chapters.

Contents

1. Transfusion in the New Millennium

Blood Components and Derivatives

Red Blood Cells

2. Red Cell Production and Kinetics
3. Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes
4. Red Blood Cell Metabolism and Preservation
5. Red Cell Immunology and Compatibility Testing
6. Carbohydrate Blood Groups
7. Rh and LW Blood Groups
8. Other Protein Blood Groups
9. Anemia and Red Blood Cell Transfusion

Platelets

10. Platelet Production, Kinetics, and Hemostasis
11. Platelet Immunology and Alloimmunization
12. Preparation, Preservation, and Storage of Platelet Concentrates
13. Thrombocytopenia and Platelet Transfusion

White Blood Cells

14. Neutrophil Production and Kinetics: Neutropenia and Neutrophilia
15. Neutrophil Collection and Transfusion
16. Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects

Plasma

Composition and Mechanisms of Blood Coagulation and Fibrinolysis
1. Immunoglobulins
2. Preparation and Use of Plasma Derivatives
3. Plasma Transfusion and Use of Albumin

Cell Kinetics

21. Applications of Cellular Radiolabeliing in Transfusion Medicine

Clinical Practice

Medical Patients

Autoimmune Hemolytic Anemia and Paroxysmal Noctural Hemoglobinuria
1. Management of Immune Thrombocytopenias
2. Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy

Obstetric and Pediatric Patients

25. Fetal and Neonatal Hematopoiesis
26. Obstetric Transfusion Practice
27. Hemolytic Disease of the Newborn
28. Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics
29. Management of Congenital Hemolytic Anemias
30. Blood Component Transfusions for Infants

Oncology Patients

31. Transfusion Support for the Oncology Patient
32. Hematopoietic Growth Factors (Cytokines)
33. Hematopoietic Progenitor Cells: Biology and Processing
34. Hematopoietic Progenitor Cells: Autologous Transplantation
35. Hematopoietic Progenitor Cells: Allogeneic Transplantation
36. Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation

Surgery Patients

37. Alternatives to Transfusion: Perioperative Blood Management
38. Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures
39. Transfusion Therapy in the Care of Trauma and Burn Patients
40. Transfusion Therapy in Solid-Organ Transplantation

Apheresis

41. Apheresis: Principles and Technology of Hemapheresis
42. Therapeutic Plasma Exchange
43. Specialized Therapeutic Hemapheresis and Phlebotomy

Hazards of Transfusion

Hemovigilance

44. Overview of Hemovigilance
45. Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Tranfusion

Infectious Hazards of Transfusion

46. Transfusion-Transmitted Hepatitis
47. Retroviruses and Other Viruses
48. Transfusion Transmission of Parasites
49. Bacterial Contamination of Blood Products
50. Prion Diseases
51. Pathogen Inactivation

Noninfectious Hazards

52. Hemolytic Transfusion Reactions
53. Febrile, Allergic, and Nonimmune Transfusion Reactions
54. Transfusion-Associated Graft-vs-Host Disease
55. Tranfusional Iron Overload
56. Transfusion-Related Acute Lung Injury

Cell and Tissue Therapy

57. HLA Antigens and Alleles
58. Tissue Banking
59. Adoptive Immunotherapy
60. Gene Therapy in Transfusion Medicine
61. Tissue Engineering and Regenerative Medicine

Delivery of Transfusion and Transplantation Services

62. Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood
63. Current Legal Issues in Transfusion Medicine
64. Current Good Manufacturing Practice
65. Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs
66. Hospital Transfusion Committee and Quality Assurance

Index

Companion PC and Mac Compatible CD-ROMs

CD-ROM 1:

• All chapters of the book with a full text search function

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