Pulmonary Diseases Handbook from C.H.I.P.S.

Pulmonary Diseases and Disorders
Fourth edition
Two-Volume Set

edited by
Alfred P. Fishman

Fishman's Pulmonary Diseases and Disorders is a complete guide to the entire field of respiratory medicine. It covers exactly what you need to know about lung diseases and their management, including sleep-disordered breathing, COPD, emphysema, and lung cancer, as well as new technological advances and imaging techniques.

This unparalleled two-volume resource begins with a compelling overview of up-to-date clinical perspectives, along with the scientific basis of lung function health and disease. It then provides turnkey information on everything from respiratory disease signs and symptoms, to obstructive lung diseases, occupational and environmental disorders, and specific respiratory conditions such as infections diseases of the lungs and acute respiratory failure.

New to the 4th Edition:

  • Information on recent advancements in many clinically relevant areas of pulmonary medicine
  • Update to the infectious diseases chapters that reflect current practice guidelines and recent antimicrobial developments
  • Clearer connection between fundamental science concepts and clinical applications, which reflect current scientific research
  • Latest information on sleep disorders
  • Review of recent recommendations of the American Thoracic Society and European Respiratory Society for the accurate interpretation of pulmonary function tests
  • Appendices that include a respiratory questionnaire, normal values, and commonly used terms and symbols


Volume One

Part One: Perspectives

  1. Milestones in the History of Pulmonary Medicine

Part Two: Scientific Basis of Lung Function in Health and Disease

  1. Functional Design of the Human Lung for Gas Exchange
  2. The Respiratory Muscles
  3. Cellular Mechanisms of Lung Development
  4. Development and Growth of the Lung
  5. Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology
  6. Surfactant and Associated Proteins
  7. Transport Function of Airway Epithelia and Submucosal Glands
  8. Nonrespiratory Functions of the Lungs
  9. Pulmonary Mechanics
  10. Control of Ventilation
  11. Ventilation, Pulmonary Blood Flow, and Ventilation-Perfusion Relationships
  12. Diffusion, Chemical Reactions Involving Respiratory Gases, and Diffusing Capacity
  13. Blood-Gas Transport
  14. Acid-Base Balance
  15. Exercise, Integration, and Adaptation
  16. Breathing during Exercise
  17. The Lungs in Pregnancy
  18. Aging of the Respiratory System
  19. Pulmonary Defense Mechanisms against Infections
  20. Lymphocyte- and Macrophage-Mediated Inflammation in the Lung
  21. Mast Cells and Eosinophils
  22. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency
  23. Cytokines and Chemokines in Lung Inflammation and Injury
  24. Leukocyte Accumulation in the Lung
  25. Nitric Oxide and Lung Injury
  26. The Pathogenesis of Pulmonary Fibrosis

Part Three: Symptoms and Signs of Respiratory Disease

  1. Approach to the Patient with Respiratory Symptoms
  2. Pulmonary Cutaneous Disorders
  3. Pulmonary-Systemic Interactions
  4. Principles of Effective Care
  5. Radiographic Evaluation of the Chest
  6. Pulmonary Cytopathology
  7. Angiographic Techniques in the Evaluation and Management of Suspected Pulmonary Disease
  8. Scintigraphic Evaluation of Pulmonary Disease
  9. Pulmonary Function Testing
  10. Principles and Applications of Cardiopulmonary Exercise Testing
  11. Bronchoscopy, Transthoracic Needle Aspiration, and Related Procedures
  12. Thoracoscopy
  13. Perioperative Respiratory Considerations in the Surgical Patient
  14. Impairment and Disability Evaluation in Lung Disease

Part Four: Obstructive Lung Diseases

  1. Chronic Obstructive Lung Disease: Overview
  2. Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, and Pathogenesis
  3. Chronic Obstructive Pulmonary Disease: Clinical Course and Management
  4. Cigarette Smoking and Disease
  5. Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders
  6. The Biology of Asthma
  7. Asthma: Epidemiology
  8. Aspirin- and Exercise-Induced Asthma
  9. Asthma: Clinical Presentation and
  10. Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Reactions to Fungi
  11. Upper Airway Obstruction
  12. Cystic Fibrosis
  13. Bronchiolitis
  14. Bullous Diseases of the Lungs

Part Five: Occupational and Environmental Disorders

  1. Occupational Lung Disorders: General Principles and Approaches
  2. Asbestos-Related Lung Disease
  3. Chronic Beryllium and Hard-Metal Lung Disease
  4. Coal Workers’ Lung Diseases and Silicosis
  5. Occupational Asthma, Byssinosis, and Industrial Bronchitis
  6. Toxic Inhalations
  7. Indoor and Outdoor Air Pollution
  8. Pulmonary Adaptation and Clinical Disorders Related to High Altitude
  9. Diving Injuries and Air Embolism
  10. Thermal Lung Injury and Acute Smoke Inhalation

Part Six: Drug-Induced Lung Diseases

  1. Pulmonary Toxicity Associated with Chemotherapeutic Agents
  2. Drug-Induced Lung Disease due to Nonchemotherapeutic Agents

Part Seven: Interstitial and Inflammatory Lung Diseases

  1. Interstitial Lung Disease: A Clinical Overview and General Approach
  2. Systemic Sarcoidosis
  3. Idiopathic Pulmonary Fibrosis
  4. Hypersensitivity Pneumonitis
  5. Radiation Pneumonitis
  6. Pulmonary Manifestations of the Collagen Vascular Diseases
  7. The Eosinophilic Pneumonias
  8. Depositional Diseases of the Lungs
  9. Pulmonary Histiocytosis X
  10. Pulmonary Lymphangioleiomyomatosis
  11. The Lungs in Patients with Inborn Errors of Metabolism

Part Eight: Alveolar Diseases

  1. Alveolar Hemorrhage Syndromes
  2. Mechanisms of Aspiration Disorders
  3. Pulmonary Alveolar Proteinosis

Volume Two

Part Nine: Disorders of the Pulmonary Circulation

  1. The Pulmonary Circulation
  2. Pulmonary Hypertension and Cor Pulmonale
  3. Pulmonary Thromboembolic Disease
  4. Pulmonary Edema
  5. Pulmonary Vasculitis
  6. Pulmonary Arteriovenous Malformations

Part Ten: Disorders of the Pleural Space

  1. Pleural Fluid Dynamics and Effusions
  2. Nonmalignant Pleural Effusions
  3. Malignant Pleural Effusions
  4. Pneumothorax
  5. Malignant Mesothelioma and Other Primary Pleural Tumors

Part Eleven: Diseases of the Mediastinum

  1. The Mediastinum: Overview, Anatomy, and Diagnostic Approach
  2. Nonneoplastic Disorders of the Mediastinum
  3. Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies
  4. Acquired Lesions of the Mediastinum: Benign and Malignant

Part Twelve: Disorders of the Chest Wall, Diaphragm, and Spine

  1. Nonmuscular Diseases of the Chest Wall
  2. Effects of Neuromuscular Diseases on Ventilation
  3. Pulmonary Rehabilitation in Neuromuscular Diseases

Part Thirteen: Sleep and Sleep Disorders

  1. The Stages of Sleep
  2. Changes in the Cardiorespiratory System during Sleep
  3. Sleep Apnea Syndromes
  4. Differential Diagnosis and Evaluation of Sleepiness

Part Fourteen: Surgical Aspects of Pulmonary Medicine

  1. Perioperative Care of the Patient Undergoing Lung Resection
  2. Thoracic Trauma
  3. Lung Transplantation

Part Fifteen: Neoplasms of the Lungs

  1. Genetic and Molecular Changes of Human Lung Cancer
  2. Epidemiology of Lung Cancer
  3. Cigarette Smoking and Health Policy
  4. The Solitary Pulmonary Nodule: A Systemic Approach
  5. The Pathology of Non–Small Cell Lung Carcinoma
  6. Non–Small Cell Lung Cancer—Clinical Aspects, Diagnosis, Staging, and Natural History
  7. Part I: Treatment of Non–Small Cell Lung Cancer: Surgical
    Part II: Treatment of Non–Small Cell Lung Cancer: Chemotherapy
    Part III: Treatment of Non–Small Cell Lung Cancer: Radiation Therapy
  8. Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History
  9. Primary Lung Tumors Other Than Bronchogenic Carcinoma: Benign and Malignant
  10. Extrapulmonary Syndromes Associated with Lung Tumors
  11. Pulmonary Metastases
  12. Lymphoproliferative and Hematologic Diseases Involving the Lung

Part Sixteen: Infectious Diseases of the Lungs

  1. Microbial Flora and Colonization of the Respiratory Tract
  2. Pulmonary Clearance of Infectious Agents
  3. Approach to the Patient with Pulmonary Infections
  4. Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia
  5. Local Therapy and Pharmacokinetics of Antibiotics in the Lungs
  6. Vaccination for Pulmonary Infections
  7. Microbial Virulence Factors in Pulmonary Infections
  8. Infections of the Upper Respiratory Tract
  9. Acute Bronchitis and Community-Acquired Pneumonia
  10. Pneumonia in Childhood
  11. Aspiration Disease and Anaerobic Infection
  12. Empyema and Lung Abscess
  13. Mediastinitis
  14. Bronchiectasis
  15. Systemic Infection, the Sepsis Syndrome, and the Lungs
  16. Special Hosts and Opportunistic Infections
  17. Introduction: Pulmonary Infection in Special Hosts
  18. HIV Infection and Opportunistic Pulmonary Infections in AIDS
  19. Pulmonary Infections in Neutropenia and Cancer
  20. Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation
  21. Pneumonia in the Organ Transplant Patient
  22. Pulmonary Infections in Patients with Primary Immune Defects
  23. Postoperative Pneumonia
  24. Respiratory Infections in the Economically Disadvantaged
  25. Pneumonias Caused by Gram-Positive Bacteria
  26. Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia
  27. Legionellosis
  28. Mycoplasma, Chlamydia, and “Atypical Pneumonias”
  29. Actinomycosis and Nocardiosis
  30. Aspergillus Syndromes, Mucormycosis,and Pulmonary Candidiasis
  31. Endemic Mycoses of North America: Histoplasmosis, Coccidioidomycosis, and Blastomycosis
  32. Cryptococcal Infections
  33. Pneumocystis Carinii
  34. Viral Infections of the Lung and Respiratory Tract
  35. The Lung in Human Immunodeficiency Virus Infection
  36. Emerging Infectious Diseases and Hantavirus Pulmonary Syndromev
  37. Poliovirus and Other Enterovirus Infections
  38. Protozoan Infections of the Thorax
  39. Helminthic Diseases of the Lungs
  40. Zoonotic and Other Unusual Bacterial Pneumonias
  41. The Epidemiology, Transmission, and Prevention of Tuberculosis in the United States
  42. The Microbiology of the Mycobacteria
  43. Pathogenesis of Pulmonary Tuberculosis
  44. Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations
  45. Clinical Presentation and Treatment of Tuberculosis
  46. Mycobacterial Infections and HIV Infection
  47. Diseases due to Mycobacteria Other than Mycobacterium Tuberculosis

Part Seventeen: Acute Respiratory Failure

  1. Respiratory Failure: An Overview
  2. Acute Respiratory Distress Syndrome:Pathogenesis
  3. Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcome
  4. The Systemic Inflammatory Response Syndrome and the Multiple Organ Dysfunction Syndrome
  5. Respiratory Distress Syndrome in Premature Newborn Infants
  6. Acute Respiratory Failure in the Surgical Patient
  7. Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease
  8. Oxygen Therapy and Pulmonary Oxygen Toxicity
  9. Pulmonary Pharmacotherapy
  10. Intubation and Upper Airway Management
  11. Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure
  12. Mechanical Ventilation: Conventional Modes and Settings
  13. Mechanical Ventilation: Physiological Considerations and New Ventilatory Techniques
  14. Nutrition in Acute Respiratory Failure
  15. Treatment of Agitation and Distress in Mechanically Ventilated Patients
  16. Decision Making in the Intensive Care Unit
  17. Ethics in the Intensive Care Unit
  18. Prevention and Control of Lung Disease


  • Respiratory Questionnaire
  • Normal Values
  • Terms and Symbols in Respiratory Physiology


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Pulmonary Diseases and Disorders
Fourth edition
Two-Volume Set

edited by Alfred P. Fishman
2006 • 2-Volume Set • $464.00 + shipping
Texas residents please add 6.75 % sales tax

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