Fishman's Pulmonary Diseases and Disorders is a complete guide to the entire field of respiratory medicine. It covers exactly what you need to know about lung diseases and their management, including sleep-disordered breathing, COPD, emphysema, and lung cancer, as well as new technological advances and imaging techniques.

This unparalleled two-volume resource begins with a compelling overview of up-to-date clinical perspectives, along with the scientific basis of lung function health and disease. It then provides turnkey information on everything from respiratory disease signs and symptoms, to obstructive lung diseases, occupational and environmental disorders, and specific respiratory conditions such as infections diseases of the lungs and acute respiratory failure.

New to the 4th Edition:

• Information on recent advancements in many clinically relevant areas of pulmonary medicine
• Update to the infectious diseases chapters that reflect current practice guidelines and recent antimicrobial developments
• Clearer connection between fundamental science concepts and clinical applications, which reflect current scientific research
• Latest information on sleep disorders
• Review of recent recommendations of the American Thoracic Society and European Respiratory Society for the accurate interpretation of pulmonary function tests
• Appendices that include a respiratory questionnaire, normal values, and commonly used terms and symbols

CONTENTS

Volume One

Part One: Perspectives

1. Milestones in the History of Pulmonary Medicine

Part Two: Scientific Basis of Lung Function in Health and Disease

2. Functional Design of the Human Lung for Gas Exchange
3. The Respiratory Muscles
4. Cellular Mechanisms of Lung Development
5. Development and Growth of the Lung
6. Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology
7. Surfactant and Associated Proteins
8. Transport Function of Airway Epithelia and Submucosal Glands
9. Nonrespiratory Functions of the Lungs
10. Pulmonary Mechanics
11. Control of Ventilation
12. Ventilation, Pulmonary Blood Flow, and Ventilation-Perfusion Relationships
13. Diffusion, Chemical Reactions Involving Respiratory Gases, and Diffusing Capacity
14. Blood-Gas Transport
15. Acid-Base Balance
16. Exercise, Integration, and Adaptation
17. Breathing during Exercise
18. The Lungs in Pregnancy
19. Aging of the Respiratory System
20. Pulmonary Defense Mechanisms against Infections
21. Lymphocyte- and Macrophage-Mediated Inflammation in the Lung
22. Mast Cells and Eosinophils
23. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency
24. Cytokines and Chemokines in Lung Inflammation and Injury
25. Leukocyte Accumulation in the Lung
26. Nitric Oxide and Lung Injury
27. The Pathogenesis of Pulmonary Fibrosis

Part Three: Symptoms and Signs of Respiratory Disease

28. Approach to the Patient with Respiratory Symptoms
29. Pulmonary Cutaneous Disorders
30. Pulmonary-Systemic Interactions
31. Principles of Effective Care
32. Radiographic Evaluation of the Chest
33. Pulmonary Cytopathology
34. Angiographic Techniques in the Evaluation and Management of Suspected Pulmonary Disease
35. Scintigraphic Evaluation of Pulmonary Disease
36. Pulmonary Function Testing
37. Principles and Applications of Cardiopulmonary Exercise Testing
38. Bronchoscopy, Transthoracic Needle Aspiration, and Related Procedures
39. Thoracoscopy
40. Perioperative Respiratory Considerations in the Surgical Patient
41. Impairment and Disability Evaluation in Lung Disease

Part Four: Obstructive Lung Diseases

42. Chronic Obstructive Lung Disease: Overview
43. Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, and Pathogenesis
44. Chronic Obstructive Pulmonary Disease: Clinical Course and Management
45. Cigarette Smoking and Disease
46. Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders
47. The Biology of Asthma
48. Asthma: Epidemiology
49. Aspirin- and Exercise-Induced Asthma
50. Asthma: Clinical Presentation and
51. Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Reactions to Fungi
52. Upper Airway Obstruction
53. Cystic Fibrosis
54. Bronchiolitis
55. Bullous Diseases of the Lungs

Part Five: Occupational and Environmental Disorders

56. Occupational Lung Disorders: General Principles and Approaches
57. Asbestos-Related Lung Disease
58. Chronic Beryllium and Hard-Metal Lung Disease
59. Coal Workers’ Lung Diseases and Silicosis
60. Occupational Asthma, Byssinosis, and Industrial Bronchitis
61. Toxic Inhalations
62. Indoor and Outdoor Air Pollution
63. Pulmonary Adaptation and Clinical Disorders Related to High Altitude
64. Diving Injuries and Air Embolism
65. Thermal Lung Injury and Acute Smoke Inhalation

Part Six: Drug-Induced Lung Diseases

66. Pulmonary Toxicity Associated with Chemotherapeutic Agents
67. Drug-Induced Lung Disease due to Nonchemotherapeutic Agents

Part Seven: Interstitial and Inflammatory Lung Diseases

68. Interstitial Lung Disease: A Clinical Overview and General Approach
69. Systemic Sarcoidosis
70. Idiopathic Pulmonary Fibrosis
71. Hypersensitivity Pneumonitis
72. Radiation Pneumonitis
73. Pulmonary Manifestations of the Collagen Vascular Diseases
74. The Eosinophilic Pneumonias
75. Depositional Diseases of the Lungs
76. Pulmonary Histiocytosis X
77. Pulmonary Lymphangioleiomyomatosis
78. The Lungs in Patients with Inborn Errors of Metabolism

Part Eight: Alveolar Diseases

79. Alveolar Hemorrhage Syndromes
80. Mechanisms of Aspiration Disorders
81. Pulmonary Alveolar Proteinosis

Volume Two

Part Nine: Disorders of the Pulmonary Circulation

82. The Pulmonary Circulation
83. Pulmonary Hypertension and Cor Pulmonale
84. Pulmonary Thromboembolic Disease
85. Pulmonary Edema
86. Pulmonary Vasculitis
87. Pulmonary Arteriovenous Malformations

Part Ten: Disorders of the Pleural Space

88. Pleural Fluid Dynamics and Effusions
89. Nonmalignant Pleural Effusions
90. Malignant Pleural Effusions
91. Pneumothorax
92. Malignant Mesothelioma and Other Primary Pleural Tumors

Part Eleven: Diseases of the Mediastinum

93. The Mediastinum: Overview, Anatomy, and Diagnostic Approach
94. Nonneoplastic Disorders of the Mediastinum
95. Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies
96. Acquired Lesions of the Mediastinum: Benign and Malignant

Part Twelve: Disorders of the Chest Wall, Diaphragm, and Spine

97. Nonmuscular Diseases of the Chest Wall
98. Effects of Neuromuscular Diseases on Ventilation
99. Pulmonary Rehabilitation in Neuromuscular Diseases

Part Thirteen: Sleep and Sleep Disorders

100. The Stages of Sleep
101. Changes in the Cardiorespiratory System during Sleep
102. Sleep Apnea Syndromes
103. Differential Diagnosis and Evaluation of Sleepiness

Part Fourteen: Surgical Aspects of Pulmonary Medicine

104. Perioperative Care of the Patient Undergoing Lung Resection
105. Thoracic Trauma
106. Lung Transplantation

Part Fifteen: Neoplasms of the Lungs

107. Genetic and Molecular Changes of Human Lung Cancer
108. Epidemiology of Lung Cancer
109. Cigarette Smoking and Health Policy
110. The Solitary Pulmonary Nodule: A Systemic Approach
111. The Pathology of Non–Small Cell Lung Carcinoma
112. Non–Small Cell Lung Cancer—Clinical Aspects, Diagnosis, Staging, and Natural History
113. Part I: Treatment of Non–Small Cell Lung Cancer: Surgical
     Part II: Treatment of Non–Small Cell Lung Cancer: Chemotherapy
     Part III: Treatment of Non–Small Cell Lung Cancer: Radiation Therapy
114. Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History
115. Primary Lung Tumors Other Than Bronchogenic Carcinoma: Benign and Malignant
116. Extrapulmonary Syndromes Associated with Lung Tumors
117. Pulmonary Metastases
118. Lymphoproliferative and Hematologic Diseases Involving the Lung

Part Sixteen: Infectious Diseases of the Lungs

119. Microbial Flora and Colonization of the Respiratory Tract
120. Pulmonary Clearance of Infectious Agents
121. Approach to the Patient with Pulmonary Infections
122. Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia
123. Local Therapy and Pharmacokinetics of Antibiotics in the Lungs
124. Vaccination for Pulmonary Infections
125. Microbial Virulence Factors in Pulmonary Infections
126. Infections of the Upper Respiratory Tract
127. Acute Bronchitis and Community-Acquired Pneumonia
128. Pneumonia in Childhood
129. Aspiration Disease and Anaerobic Infection
130. Empyema and Lung Abscess
131. Mediastinitis
132. Bronchiectasis
133. Systemic Infection, the Sepsis Syndrome, and the Lungs
134. Special Hosts and Opportunistic Infections
135. Introduction: Pulmonary Infection in Special Hosts
136. HIV Infection and Opportunistic Pulmonary Infections in AIDS
137. Pulmonary Infections in Neutropenia and Cancer
138. Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation
139. Pneumonia in the Organ Transplant Patient
140. Pulmonary Infections in Patients with Primary Immune Defects
141. Postoperative Pneumonia
142. Respiratory Infections in the Economically Disadvantaged
143. Pneumonias Caused by Gram-Positive Bacteria
144. Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia
145. Legionellosis
146. Mycoplasma, Chlamydia, and “Atypical Pneumonias”
147. Actinomycosis and Nocardiosis
148. Aspergillus Syndromes, Mucormycosis,and Pulmonary Candidiasis
149. Endemic Mycoses of North America: Histoplasmosis, Coccidioidomycosis, and Blastomycosis
150. Cryptococcal Infections
151. Pneumocystis Carinii
152. Viral Infections of the Lung and Respiratory Tract
153. The Lung in Human Immunodeficiency Virus Infection
154. Emerging Infectious Diseases and Hantavirus Pulmonary Syndromev
155. Poliovirus and Other Enterovirus Infections
156. Protozoan Infections of the Thorax
157. Helminthic Diseases of the Lungs
158. Zoonotic and Other Unusual Bacterial Pneumonias
159. The Epidemiology, Transmission, and Prevention of Tuberculosis in the United States
160. The Microbiology of the Mycobacteria
161. Pathogenesis of Pulmonary Tuberculosis
162. Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations
163. Clinical Presentation and Treatment of Tuberculosis
164. Mycobacterial Infections and HIV Infection
165. Diseases due to Mycobacteria Other than Mycobacterium Tuberculosis

Part Seventeen: Acute Respiratory Failure

166. Respiratory Failure: An Overview
167. Acute Respiratory Distress Syndrome:Pathogenesis
168. Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcome
169. The Systemic Inflammatory Response Syndrome and the Multiple Organ Dysfunction Syndrome
170. Respiratory Distress Syndrome in Premature Newborn Infants
171. Acute Respiratory Failure in the Surgical Patient
172. Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease
173. Oxygen Therapy and Pulmonary Oxygen Toxicity
174. Pulmonary Pharmacotherapy
175. Intubation and Upper Airway Management
176. Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure
177. Mechanical Ventilation: Conventional Modes and Settings
178. Mechanical Ventilation: Physiological Considerations and New Ventilatory Techniques
179. Nutrition in Acute Respiratory Failure
180. Treatment of Agitation and Distress in Mechanically Ventilated Patients
181. Decision Making in the Intensive Care Unit
182. Ethics in the Intensive Care Unit
183. Prevention and Control of Lung Disease

Appendices

• Respiratory Questionnaire
• Normal Values
• Terms and Symbols in Respiratory Physiology

Index

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