Sepsis brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches.

Sepsis covers:

• adaptive immunity
• inflammation
• neuroendocrinology
• bioenergetics
• metabolism

Contents

1. Strategies to modulate cellular energetic metabolism during sepsis
2. Immunostimulation is a rational therapeutic strategy in sepsis
3. Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis
4. Modulating neutrophil apoptosis
5. HMGB1 as a potential therapeutic target
6. Poly (ADP-ribose) polymerase activation and circulatory shock
7. Choosing the right substrate
8. Inhibiting glycogen synthase kinase 3β in sepsis
9. Ethyl pyruvate: a novel treatment for sepsis
10. Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models
11. The hypothalamic pituitary adrenal axis in sepsis
12. Modulating the endocrine response in sepsis: insulin and blood glucose control
13. The neuronal strategy for inflammation
14. Beta-blockade in burns
15. System interactions
16. Protecting the permeability pore and mitochondrial biogenesis

Index

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