Severe Pneumonia explores factors that lead to the development of severe pneumonia, the most effective treatment methods for the condition, and recent efforts to improve disease outcomes-describing patients at risk for severe pneumonia, mortality predictors in ventilator-associated pneumonia, and mechanisms of antibiotic resistance in the intensive care unit.

Features:

• Examines the pathogenesis, bacteriology, and key clinical features associated with severe pneumonia
• Details the role of mechanical ventilation in the pathogenesis of illness
• Reviews appropriate dosing and dosing regimens for antibiotic therapy
• Discusses controversies surrounding the use of mono vs. combination therapy for the management of ventilator-associated pneumonia
• Examines the role of microbiological surveillance in the management of ventilator-associated pneumonia
• Analyzes controversies in the diagnosis of pneumonia
• Considers the optimization of pharmacokinetic and pharmacodynamic approaches for the treatment of patients with severe pneumonia
• Presents new approaches in the treatment and prevention of ventilator-associated pneumonia

Contents

• Severe Pneumonia: Definition of Severity
• Why do Some Patient Get Severe Pneumonia
• What is the Role of Mechanical Ventilation in Pneumonia Pathogenesis and How can Non-Invasive Ventilation be Used to Prevent Nosocomial Pneumonia
• Defining the Patient at Risk of Severe Illness and the Role of Mortality Prediction Models in Patient Management
• The Bacteriology of Severe Community-Acquired Pneumonia and the Choice of Appropriate Empiric Therapy
• Risk Factors for Ventilator-Associated Pneumonia
• Attributable Mortality and Mortality Predictors in Ventilator-Associated Pneumonia
• Establishing the Diagnosis of Ventilator-Associated Pneumonia
• Establishing the Clinical Diagnosis of Ventilator-Associate Pneumonia: An Invasive/Microbiologic Approach
• Mechanisms of Antibiotic Resistance in the Intensive Care Unit
• What are the Optical Regimens for Adequate Empiric Therapy of Ventilator-Associated Pneumonia and How can Descalation Therapy be Achieved

Index

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