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Sleep and Sleep Disorders
A Neuropsychopharmacological Approach
edited by Malcolm Lader

Sleep and Sleep Disorders serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine.

The goal of Sleep and Sleep Disorders is to:

  • present the more recent developments and advances in the fields of sleep and neuropsychopharmacology
  • provide a context for considering them both in depth and from multidisciplinary perspectives

Sleep and Sleep Disorders brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms.

Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this will serve as a foundation for understanding, and ultimately treating, sleep disorders.


Basic Pharmacology

  1. GABAA Receptor Subtypes in Sedation and Hypnosis
  2. Sleep Hippocampal Theta Rhythm and Sensory Processing
  3. Monoaminergic Mechanisms in the Regulation of Sleep-Wakefulness: Special Emphasis on Preoptic Noradrenergic System
  4. REM Sleep Function and Brain Monoamine Regulation: An Application of the Search Activity Concept
  5. Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye Movement Sleep
  6. The Mechanistic Relationship between NREM Sleep and Anesthesia


  1. Time-Dependent Psychotropic Drug Effects Hints of Pharmacochronomics, Broader than Circadian Time Structures
  2. Melatonin Interaction with Bz-Gabaa Receptors: Implications for Sleep Induction
  3. Melatonin: A Chronobiotic that Not Only Shifts Rhythms
  4. Melatonin and Human Sleep
  5. Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer’s Disease
  6. Pharmacotherapy for Seasonal Affective Disorder
  7. Use and Discontinuation of Hypnosedative Medications

Clinical Pharmacology

  1. Long-Term Use of Sleeping Pills in Chronic Insomnia
  2. Risks of Chronic Hypnotic Use
  3. Effects of Psychotropics on Driving Performance
  4. Diagnosis, Pathophysiology and Treatment of Hypersomnias
  5. Chronic Disease and Sleep Architecture Pharmacotherapeutic Considerations
  6. Benzodiazepines for Sedation in Infants and Children
  7. The Pharmacological Management of Fatigue and Sleepiness in Affective Disorders
  8. Next-Day Residual Effects of Sleeping Medications on Driving Ability: A Review of the Literature
  9. Sleep and Pain
  10. Head Injuries and Sleep
  11. Psychopharmacological Management of Restless Legs Syndrome and Periodic Limb Movements in Sleep
  12. A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient’s Estimate of Sleep Quality
  13. The Pharmacostrategy of Treating Sleep Disorders in Parkinsonism
  14. The Neuropharmacology of Nightmares
  15. The Night Eating Syndrome
  16. Drug Effects on Dreaming
  17. Sleep Problems in Primary Care
  18. SSRIs and Sleep in Man
  19. Sleep and Antipsychotic Drugs in Schizophrenia Patients
  20. Sleep and Epilepsy: From Interrelationships to Influence of Antiepileptic Drugs
  21. Herbal Medicines and Sleep


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Sleep and Sleep Disorders
A Neuropsychopharmacological Approach
edited by Malcolm Lader

2006 • 309 pages • $188.00 + shipping
Texas residents please add 6.75 % sales tax

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