Sleep and Sleep Disorders serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine.

The goal of Sleep and Sleep Disorders is to:

• present the more recent developments and advances in the fields of sleep and neuropsychopharmacology
• provide a context for considering them both in depth and from multidisciplinary perspectives

Sleep and Sleep Disorders brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms.

Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this will serve as a foundation for understanding, and ultimately treating, sleep disorders.

Contents

Basic Pharmacology

1. GABAA Receptor Subtypes in Sedation and Hypnosis
2. Sleep Hippocampal Theta Rhythm and Sensory Processing
3. Monoaminergic Mechanisms in the Regulation of Sleep-Wakefulness: Special Emphasis on Preoptic Noradrenergic System
4. REM Sleep Function and Brain Monoamine Regulation: An Application of the Search Activity Concept
5. Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye Movement Sleep
6. The Mechanistic Relationship between NREM Sleep and Anesthesia

Chronopharmacology

7. Time-Dependent Psychotropic Drug Effects Hints of Pharmacochronomics, Broader than Circadian Time Structures
8. Melatonin Interaction with Bz-Gabaa Receptors: Implications for Sleep Induction
9. Melatonin: A Chronobiotic that Not Only Shifts Rhythms
10. Melatonin and Human Sleep
11. Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer’s Disease
12. Pharmacotherapy for Seasonal Affective Disorder
13. Use and Discontinuation of Hypnosedative Medications

Clinical Pharmacology

14. Long-Term Use of Sleeping Pills in Chronic Insomnia
15. Risks of Chronic Hypnotic Use
16. Effects of Psychotropics on Driving Performance
17. Diagnosis, Pathophysiology and Treatment of Hypersomnias
18. Chronic Disease and Sleep Architecture Pharmacotherapeutic Considerations
19. Benzodiazepines for Sedation in Infants and Children
20. The Pharmacological Management of Fatigue and Sleepiness in Affective Disorders
21. Next-Day Residual Effects of Sleeping Medications on Driving Ability: A Review of the Literature
22. Sleep and Pain
23. Head Injuries and Sleep
24. Psychopharmacological Management of Restless Legs Syndrome and Periodic Limb Movements in Sleep
25. A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient’s Estimate of Sleep Quality
26. The Pharmacostrategy of Treating Sleep Disorders in Parkinsonism
27. The Neuropharmacology of Nightmares
28. The Night Eating Syndrome
29. Drug Effects on Dreaming
30. Sleep Problems in Primary Care
31. SSRIs and Sleep in Man
32. Sleep and Antipsychotic Drugs in Schizophrenia Patients
33. Sleep and Epilepsy: From Interrelationships to Influence of Antiepileptic Drugs
34. Herbal Medicines and Sleep

Index

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