Sodium Channels, Pain, and Analgesia confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression.

Sodium Channels, Pain, and Analgesia provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain.

Contents

1. Voltage-gated Sodium Channels and Pain Associated with Nerve injury and Neuropathies
2. Current Approaches for the Discovery of Novel Na_vchannel Inhibitors for the Treatment of Brain Disorders
3. Voltage-gated Sodium Channels and Visceral Pain
4. The Functional Interaction of Accessory Proteins and Voltage-gated Sodium Channels
5. Sodium Channels and Nociceptive Nerve Endings
6. Signalling Cascades that Modulate the Activity of Sodium Channels in Sensory Neurons
7. Na_v1.8 as a Drug Target for Pain
8. Role of Voltage-gate Sodium Channels in Oral and Craniofacial Pain
9. Sodium Channel Gating and Drug Blockade
10. Future Directions in Sodium Channel Research

Index

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