This is the first handbook on the whole field of stem cell research covering:
- molecular and cellular fundamentals
- clinical applications
- GMP processing
Stem Cell Transplantation provides a timely overview of the potential and plasticity of adult stem cells.
With its focus on standardization and quality control of cell lines suited for processing and clinical trials, Stem Cell Transplantation features novel therapeutic approaches that offer great promise for new ways of treating neural, hematological and cardiovascular diseases.
Contents
Stem Cell Biology
Clinical Potentials of Stem Cells: Hype or Hope?
- What are Stem Cells?
- Stem Cells and Regeneration
- Adult and Embryonic Stem Cells
- In the Beginning was the Hematopoietic Stem Cell
- Trans-Differentiation of ASCs
- The Plasticity of ASCs: All Hype and no Hope?
- The Battle of Two Cultures: ESCs versus ASCs
- The Challenges for Stem Cell Technology
- Regulation of Self-Renewal versus Differentiation, Asymmetric Divisions
- Genotype and Expression Profiles of Primitive HSCs
- Maintaining Stemness: Interactions between HSCs and the Cellular Microenvironment
- Mesenchymal Stem Cells
- Preliminary Clinical Studies
Alteration of Hematopoietic Stem Cell Fates by Chromatin-Modifying Agents
- Cytotoxicity/Antitumor Activity versus Hypomethylating Effects of 5-Azacytidine and its Analogues.
- Treating HSC with 5azaD/TSA can Alter their Fate
- Are the Effects of 5azaD/TSA Due to Cytotoxicity?
- Treating HSC with Valproic Acid
- Ex-vivo Expansion of HSC Using Chromatin-Modifying Agents
- Reactivation of Gene Expression by Treating Cells with Chromatin-Modifying Agents
- Alteration of Nonhematopoietic Fate by Chromatin-Modifying Agents
- Safety/Toxicity of Treating Cells with Chromatin-Modifying Agents
Increasing Impact of Micro RNAs in Stem Cell Biology and Medicine
- Biogenesis of miRNAs
- Action Modes of miRNAs
- Potential Function Modes of miRNAs
Standardization and Quality Assurance of Stem Cell Preparations
Novel Strategies for the Mobilization of Hematopoietic Stem Cells
- Physiology of Blood Stem Cell Mobilization
- Innovative Agents for PBPC Mobilization
Pluripotent Stem Cells from Umbilical Cord Blood
- Biological Advantages of Cord Blood as a Stem Cell Resource
- The Generation and Expansion of Pluripotent Cells (USSC) from Cord Blood
- Other Multipotent Nonhematopoietic Stem Cells: Mesenchymal Cells in CB and CB Tissue
- Conclusion: Future Efforts Towards the Regenerative Capacity of CB Nonhematopoietic Cells
Good Manufacturing Practices: Clinical-Scale Production of Mesenchymal Stem Cells
- Prerequisites for the Clinical-Scale Production of MSCs
- Clinical-Scale Production: the French Experience
- QA and QC
The Clonal Activity of Marked Hematopoietic Stem Cells
- Characterization of In-vivo Clonal Activity of HSCs by Genetic Marking
- Retroviral Integration Site Analysis
- Clonality Analysis in Animal Model and Human Gene Therapy Trials
- Interaction of Retroviral Integration Site and Transgene Expression with Clonal Activity of the Respective HSC
- Clinical Interventions Affect the Clonal Activity of Marked HSCs
On the Threshold to Clinical Applications
A Large Animal Non-Injury Model for Study of Human Stem Cell Plasticity
- The Uniqueness of the Fetal Sheep Model
- Differentiative Potential of Human Cells in the Fetal Sheep Model
Developmental Potential of Somatic Stem Cells Following Injection into Murine Blastocysts
- Neurosphere Cells Generate Erythroid-Like Cells Following Injection into Early Embryos
- Hematopoietic Chimerism by Human Cord Blood-Derived HSCs
- Injection of Leukemic Cells into Blastocysts
Testing the Limits: The Potential of MAPC in Animal Models
- Characterization of MAPCs
- In-Vitro Differentiation Potential of MAPCs
- In-Vivo Differentiation Potential of MAPCs
- Mechanisms Underlying the Phenomenon of MAPCs
Mesenchymal Stem Cells as Vehicles for Genetic Targeting of Tumors
- The Tumor Stroma and its Components.
- The Role of Tumor–Stroma Interactions in Tumor Progression
- The Similarity of MSC Tumor Tropism to Wound Healing
- The Rationale for using MSCs as Cellular Delivery Vehicles
- The Challenges in Developing MSC-Based Delivery Strategies
Clinical Trials
Endothelial Progenitor Cells for Cardiac Regeneration
- Characterization of Endothelial Progenitor Cells
- Functions of EPCs to Improve Cardiac Function
- Mechanisms of Homing
- Results from Clinical Studies
Stem Cells and Bypass Grafting for Myocardial and Vascular Regeneration
- Coronary Artery Disease
- Indications for CABG Surgery
- The Rationale for Cell Therapy in CABG Patients
- The Role of Bone Marrow Cells
- Combination of (Stem) Cell Treatment with CABG Surgery
Adoptive Immunotherapy: Guidelines and Clinical Practice
- Animal Experiments
- The First Clinical Results in CML
- The EBMT Study
- The Graft-versus-Leukemia Effect
- Cytokines
- Bispecific Antibodies
- NK and NK-T Cells and HLA-Haploidentical Transplantation
- Outlook of Adoptive Immunotherapy in Chimerism
Immune Escape and Suppression by Human Mesenchymal Stem Cells
- MSCs Escape the Immune System
- Immunosuppression by MSCs
- MSC in the Clinic
Stem Cell Transplantation: The Basis for Successful Cellular Immunotherapy
- Allogeneic Stem Cell Transplantation in CLL
- Graft-versus-Leukemia Effect in CLL
- Allo-SCT with Reduced-Intensity Conditioning in CLL
- RICT from Unrelated Donors
- T-Cell Depletion
- Allo-SCT in Follicular Lymphoma
- Allo-SCT in Waldenström's Disease
Index
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