by Seok-Ki Choi

The first reference devoted solely to multivalent molecules!

Synthetic Multivalent Molecules: Concepts and Biomedical Applications presents both the basic principles of multivalent interactions and up-to-date coverage of the design concepts, synthesis, and biological activity of multivalent molecules. With a systematic summary of experimentally tested case studies, this clearly written text serves to bring together otherwise scattered research material.

Chapters cover multivalent molecules in the context of:

• Definition and structural elements
• Mechanistic basis of interaction
• Biological functions
• Biological targets in viruses, bacteria, and mammalian cells
• Methods for synthesis of multivalent molecules

Synthetic Multivalent Molecules functions admirably as both a textbook for students and a reference for libraries and professionals.

Special features include:

• more than 300 figures and illustrations that show multivalent concepts, molecular design, and chemical synthesis
• summaries of all examples in tabular form in an appendix
• an extensive bibliography referencing over 900 citations

Contents

1. Introduction.
   • Nomenclature and Definitions.
   • Mechanistic Aspects of Multivalent Interaction.
   • Biological Roles of Multivalent Ligands.

2. Multivalent Molecules Applied to Viral Targets.
   • Influenza Virus.
   • Human Immunodeficiency Virus.
   • Rotavirus.
   • Polyoma Virus.
   • Picorna Virus.
   • Respiratory Syncytial Virus.
   • Dengue Virus.
   • Nucleic Acids of Viruses.
   • Synthetic Multivalent Vaccines.

3. Multivalent Molecules Applied to Bacterial Targets.
   • Targets in Bacterial Cell Membranes.
   • Bacterial Toxins.
   • Bacterial Enzymes.
   • Bacterial Nucleic Acids.
   • Multivalent Molecules as Synthetic Vaccines.
   • Fungal Cells.

4. Multivalent Molecules Applied to Cellular Targets.
   • Carbohydrate-Recognition Receptors on Cell Surfaces.
   • Peptide and Hormone Recognition Receptors on Cell Surfaces.
   • Ligand-Mediated Receptor Dimerization.
   • Enzymes.
   • G-Protein-Coupled Receptors.
   • Ion Channels.
   • Nucleic Acids.
   • Antibodies.
   • Cell Surface Engineering.

5. Chemical Synthesis of Multivalent Molecules.
   • Selected Synthetic Methods for Multimerization.
   • Combinatorial Chemistry

Appendices
Index

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