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Drug Targeting Reference from C.H.I.P.S.

Synthetic Multivalent Molecules: Concepts
and Biomedical Applications

by Seok-Ki Choi


The first reference devoted solely to multivalent molecules!

Synthetic Multivalent Molecules: Concepts and Biomedical Applications presents both the basic principles of multivalent interactions and up-to-date coverage of the design concepts, synthesis, and biological activity of multivalent molecules. With a systematic summary of experimentally tested case studies, this clearly written text serves to bring together otherwise scattered research material.

Chapters cover multivalent molecules in the context of:

  • Definition and structural elements
  • Mechanistic basis of interaction
  • Biological functions
  • Biological targets in viruses, bacteria, and mammalian cells
  • Methods for synthesis of multivalent molecules

Synthetic Multivalent Molecules functions admirably as both a textbook for students and a reference for libraries and professionals.

Special features include:

  • more than 300 figures and illustrations that show multivalent concepts, molecular design, and chemical synthesis
  • summaries of all examples in tabular form in an appendix
  • an extensive bibliography referencing over 900 citations

Contents

  1. Introduction.
    • Nomenclature and Definitions.
    • Mechanistic Aspects of Multivalent Interaction.
    • Biological Roles of Multivalent Ligands.

  2. Multivalent Molecules Applied to Viral Targets.
    • Influenza Virus.
    • Human Immunodeficiency Virus.
    • Rotavirus.
    • Polyoma Virus.
    • Picorna Virus.
    • Respiratory Syncytial Virus.
    • Dengue Virus.
    • Nucleic Acids of Viruses.
    • Synthetic Multivalent Vaccines.

  3. Multivalent Molecules Applied to Bacterial Targets.
    • Targets in Bacterial Cell Membranes.
    • Bacterial Toxins.
    • Bacterial Enzymes.
    • Bacterial Nucleic Acids.
    • Multivalent Molecules as Synthetic Vaccines.
    • Fungal Cells.

  4. Multivalent Molecules Applied to Cellular Targets.
    • Carbohydrate-Recognition Receptors on Cell Surfaces.
    • Peptide and Hormone Recognition Receptors on Cell Surfaces.
    • Ligand-Mediated Receptor Dimerization.
    • Enzymes.
    • G-Protein-Coupled Receptors.
    • Ion Channels.
    • Nucleic Acids.
    • Antibodies.
    • Cell Surface Engineering.

  5. Chemical Synthesis of Multivalent Molecules.
    • Selected Synthetic Methods for Multimerization.
    • Combinatorial Chemistry

Appendices
Index

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Synthetic Multivalent Molecules:
Concepts and Biomedical Applications

by Seok-Ki Choi
418 pages $124.00 + shipping

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