A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics.

The Fourth edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology – and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field.

Contents

Part I: Introduction

1. Introduction
2. Introduction to Biochemical and Molecular Methods in Toxicology

Part II. Classes of Toxicants

3. Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings
4. Classes of Toxicants: Use Classes

Part III. Toxicant Processing In Vivo

5. Absorption and Distribution of Toxicants
6. Metabolism of Toxicants
7. Reactive Metabolites
8. Chemical and Physiological Influences on Xenobiotic Metabolism
9. Elimination of Toxicants

Part IV. Toxic Action

10. Acute Toxicity
11. Chemical Carcinogenesis
12. Teratogenesis

Part V. Organ Toxicity

13. Hepatotoxicity
14. Nephrotoxicity
15. Toxicology of the Nervous System
16. Reproductive System
17. Endocrine System
18. Respiratory Toxicity
19. Immunotoxicity

Part VI. Applied Toxicology

20. Toxicity Testing
21. Forensic and Clinical Toxicology
22. Prevention of Toxicity
23. Human Health Risk Assessment

Part VII. Environmental Toxicology

24. Toxicant Analysis
25. Basics of Environmental Toxicology
26. Transport and Fate of Toxicants in the Environment
27. Ecological Risk Assessment

Part VIII. New Approaches in Toxicology

28. Perspectives on Informatics in Toxicology
29. Future Considerations

Index

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