Therapeutic Monoclonal Antibodies is the first book that draws together all of the latest findings, tools, and practices that span the entire process of discovery, development, and clinical application of therapeutic monoclonal antibodies.

Coverage includes:

• Basic antibody biology and antibody sources
• Antibody engineering
• Physiology and in vivo biology
• Antibody production and delivery
• Antibody therapeutic targets
• Therapeutic monoclonal antibodies in clinical use and in clinal trial
• Biogenerics/biosimilars

Contents

Part I: Antibody Basics

1. Therapeutic Monoclonal Antibodies: Past, Present, and Future
2. Antibody Molecular Structure
3. Glycosylation of Therapeutic IgGs
4. Antibody Databases and Tools: The IMGTw Experience

Part II: Antibody Sources

5. Human Antibodies from Transgenic Mice
6. Rabbit Hybridoma
7. Human Antibody Repertoire Libraries

Part III: In Vitro Display Technology

8. Antibody Phage Display
9. Yeast Surface Display
10. Ribosomal Display
11. Bacterial Display of Antibodies
12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells

Part IV: Antibody Engineering

13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques
14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor
15. Engineering the Antibody Fc Region for Optimal Effector Function

Part V: Physiology and In Vivo Biology

16. Antibody-Complement Interaction
17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications
18. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies
19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
20. Biodistribution and Imaging
21. Antibodies and the Blood-Brain Barrier

Part VI: Antibody characterization

22. Determination of Equilibrium Dissociation Constants
23. Molecular and Functional Characterization of Monoclonal Antibodies
24. Characterization of Heterogeneity in Monoclonal Antibody Products

Part VII: Antibody Expression

25. Antibody Expression in Mammalian Cells
26. Production of Antibodies in Pichia pastoris
27. Production of Antibody Fab¹ Fragments in E. coli
28. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs
29. Production of Antibodies in Plants

Part VIII: Therapeutic Antibodies

30. The Formulation and Delivery of Monoclonal Antibodies
31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
32. Follow-On Protein Products: What, Where, When, How
33. Monomeric Fc Fusion Molecules
34. Radioimmunotherapy: Current Status and Future Directions
35. Antibody-Drug Conjugate Therapy

Abbreviations
Index

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