Thrombocytopenia offers an all-encompassing approach to the pathogenesis and treatment of thrombocytopenic disorders.

Features:

• Reviews the biology of megakaryocytes and the mechanisms and regulation of platelet production
• Considers the role of thrombopeietin and other cytokines in thrombopoiesis, and the development of new thrombopoietin analogues for clinical use
• Covers a variety of thrombocytopenic disorders associated with diminished platelet production, such as aplastic anemia and myelodysplasia
• Discusses the pathogenesis, diagnosis, and management of congenital thrombocytopenias
• Contains sections on the immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP) and the hemolytic uremic syndrome (HUS), pregnancy specific thrombocytopenic disorders such as preeclampsia and the HELLP syndrome, and thrombocytopenia caused by heparin and other drugs
• Analyzes the indications, available products, and complications of platelet transfusions, including alloimmunization and platelet refractoriness

Contents

Thrombocytopenia Due to Diminished Platelet Production

• Overview and Biology of Platelet Production
• Thrombopoietin: Biology, Clinical Studies, and Potential as a Therapeutic Agent
• Inherited Thrombocytopenias
• Miscellaneous Thrombocytopenias Due to Decreased Platelet Production

Thrombocytopenia Due to Excessive Platelet Destruction

• Overview of Platelet Clearance Mechanisms
• Immune Thrombocytopenic Purpura
• Drug-Induced Thrombocytopenia
• Heparin-Induced Thrombocytopenia
• Neonatal alloimmune Thrombocytopenia
• Thrombotic Microangiopathies: TTP and HUS
• Thrombocytopenia in Pregnancy
• Platelet Transfusion: Indications and Adverse Effects

Index

click here to see books • videos • cd-roms of related interest