Contents

Coagulation and Fibrinolysis

1. Coagulation Cascade: An Overview
2. Molecular Genetics of Blood Coagulation
3. Regulation of Coagulation
4. The Tissue Factor Pathway of Coagulation
5. Fibrin Formation and Stabilization
6. Regulation of Fibrinolysis

Platelets

7. Regulation of Megakaryopoiesis
8. Platelet Morphology and Shape Change
9. Platelet Membranes and Receptors
10. Mechanisms of Platelets Activiation

Vessel Wall

11. The Endothelium in Thrombosis and Hemorrhage
12. Angiogenesis and Hemostasis
13. Vascular Response to Injury
14. Von Willebrand Factor
15. Interactions of Coagulation and Fibrinolytic Proteins with the Vessel Wall
16. Endothelium-derived Vassoactive Factors
17. Rheology

Clinical Approach to Bleeding and Thrombosis

18. Approach to Bleeding
19. Approach to Thrombosis
20. Assessment of Peripheral Arterial and Venous Thrombosis
21. Laboratory Methods in Hemostasis

Quatitative Platelet Disorders

22. Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome
23. Alloimmune Thrombocytopenias
24. Drug-induced Thrombocytopenias
25. Immune Thrombocytopenic Purpura
26. Thrombocytosis

Qualitative Platelet Disorders

27. Congenital Disorders of Platelet Function
28. Acquired Disorders of Platelet Function

Disorders of Coagulation Factors and Fibrinolysis

29. Von Willebrand Disease
30. Hemophilia-Factor VIII Deficiency
31. Other Coagulation Factor Deficiencies
32. Factor VIII and Other Coagulation Factor Inhibitors
33. Antiphospholipid Syndrome and Lupus Anticoagulants

Thrombotic Disorders

Chapters 34-36

Other Disorders of Hemostasis

Chapters 37-43

Management of Bleeding

Management of Thrombosis

Chapters 47-57

Index