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Toxicology of Glutathione Transferases
edited by Yogesh C. Awasthi

Toxicology of Glutathione Transferases provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance.

Features:

  • Provides detailed information on the structure and function of GST enzymes and their expression in mammals
  • Covers techniques for purification, quantitation, and kinetic studies with various substrates
  • Explores emerging topics such as the regulation of stress signaling by glutathione transferases and human isozymes
  • Discusses the composition of GST isozymes in human tissues
  • Supplies updated information on GST polymorphism and discusses its relevance to diseases
  • Reviews GSH and GSTs in drug research and their clinical implications in drug development
  • Provides a comprehensive account of GSTs from the historical to recent findings
  • Explains the physiologic function of GSTs and their role in signaling

Contents

  1. Ligandin and Glutathione S-Transferases: Historical Milestones
  2. Families of Glutathione Transferases
  3. Mammalian Glutathione S-Transferase Genes: Structure and Regulation
  4. Combinatorial Protein Chemistry in Three Dimensions: A Paradigm for the Evolution of Glutathione Transferases with Novel Activities
  5. Substrates and Reaction Mechanisms of GSTs
  6. Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides
  7. GST Polymorphism: Where to Now? Clinical Applications and Functional Analysis
  8. Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development
  9. Physiological Substrates of Glutathione S-Transferases
  10. Glutathione S-Transferases as Modulators of Signal Transduction
  11. Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76
  12. Glutathione S-Transferases and Oxidative Injury of Cardiovascular Tissues
  13. Mitochondrial Glutathione S-Transferase Pool in Health and Disease
  14. Activation of Microsomal Glutathione Transferase 1 in Toxicology
  15. Glutathione S-Transferase Isozyme Composition of Human Tissues
  16. Enzymology of Glutathione S-Transferases: Laboratory Methods

Index

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Toxicology of Glutathione Transferases
edited by Yogesh C. Awasthi
2006 375 pages $168.95 + shipping
Texas residents please add 6.75 % sales tax

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