Toxicology of Glutathione Transferases provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance.

Features:

• Provides detailed information on the structure and function of GST enzymes and their expression in mammals
• Covers techniques for purification, quantitation, and kinetic studies with various substrates
• Explores emerging topics such as the regulation of stress signaling by glutathione transferases and human isozymes
• Discusses the composition of GST isozymes in human tissues
• Supplies updated information on GST polymorphism and discusses its relevance to diseases
• Reviews GSH and GSTs in drug research and their clinical implications in drug development
• Provides a comprehensive account of GSTs from the historical to recent findings
• Explains the physiologic function of GSTs and their role in signaling

Contents

1. Ligandin and Glutathione S-Transferases: Historical Milestones
2. Families of Glutathione Transferases
3. Mammalian Glutathione S-Transferase Genes: Structure and Regulation
4. Combinatorial Protein Chemistry in Three Dimensions: A Paradigm for the Evolution of Glutathione Transferases with Novel Activities
5. Substrates and Reaction Mechanisms of GSTs
6. Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides
7. GST Polymorphism: Where to Now? Clinical Applications and Functional Analysis
8. Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development
9. Physiological Substrates of Glutathione S-Transferases
10. Glutathione S-Transferases as Modulators of Signal Transduction
11. Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76
12. Glutathione S-Transferases and Oxidative Injury of Cardiovascular Tissues
13. Mitochondrial Glutathione S-Transferase Pool in Health and Disease
14. Activation of Microsomal Glutathione Transferase 1 in Toxicology
15. Glutathione S-Transferase Isozyme Composition of Human Tissues
16. Enzymology of Glutathione S-Transferases: Laboratory Methods

Index

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