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Pharmacology Book from C.H.I.P.S.

Toxicologic Biomarkers
edited by Anthony P. DeCaprio

Toxicologic Biomarkers supplies numerous examples, figures, tables, and comprehensive reference listings within each chapter to provide the reader with an in-depth understanding of the subject.

Features:

  • Provides approaches for the statistical analysis of biomarker data, and discusses the potential pitfalls associated with these biomarker analyses
  • Supplies examples of emerging and exploratory biomarkers for human clinical trials, including QTC, BNP, and KIM-1
  • Discusses the validation of new preclinical toxicologic biomarkers with sections on compound selection, analytical and biological reproducibility, and data interpretation
  • Compares regulatory agency policy on the use of toxicologic biomarker data, using the U.S. Food and Drug Administration and Environmental Protection Agency as examples
  • Contains an overview of current technologies and methods used in the assessment of toxicogenomic and toxicoproteomic biomarkers, and of markers of toxicant susceptibility
  • Examines the use of biomarkers of toxicant effect and exposure in environmental and occupational epidemiology studies
  • Presents examples and case studies of the use of biomarkers in toxic tort and environmental litigation

Contents

  1. Introduction to Toxicologic Biomarkers
  2. Challenges in the Statistical Analysis of Biomarker Data
  3. Biomarkers of Toxicant Exposure
  4. Biomarkers in Environmental Epidemiology
  5. Use of Biomarkers in Health Risk Assessment
  6. Biomarkers of Toxicant Susceptibility
  7. Identification and Use of Biomarkers in Preclinical Toxicologic Safety Assessment
  8. Use of Biomarkers in Clinical Toxicology and Clinical Trials
  9. Regulatory Guidance and Validation of Toxicologic Biomarkers
  10. Use of Biomarkers in Occupational Safety and Health
  11. Toxicogenomic and Toxicoproteomic Approaches for Biomarkers
  12. Biomarkers of Chemical Warfare Agent Exposure
  13. Applications of Biomarkers in Toxic Tort and Forensic Litigation

Index

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Toxicologic Biomarkers
edited by Anthony P. DeCaprio
2006 312 pages $228.95 + shipping
Texas residents please add 6.75 % sales tax

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