Transdermal
Drug Delivery
Second Edition
edited by Richard H. Guy

Completely revised and expanded throughout, the second edition of Transdermal Drug Delivery presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug edelivery, examing topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin, from physical chemistry and assessment of drug permeability to available enhancement technologies, to regulatory approval.

Transdermal Drug Delivery describes:

• how to determine the transdermal permeability of drugs
• how rationally to select candidates for transdermal delivery
• how to choose chemical and/or physical methods to enhance skin transport
• how to solve regulatory issues

Contents

1. Feasibility Assessment in Topical and Transdermal Delivery: Mathematical Models and In Vitro Studies
2. Evaluating the Transdermal Permeability of Chemicals
3. Skin Absorption Databases and Predictive Equations
4. Partitioning of Chemicals into Skin: Results and Predictions
5. Iontophoresis: Applications in Drug Delivery and Noninvasive Monitoring
6. Skin Electroporation for Transdermal and Topical Drug Delivery
7. Sonophoresis: Ultrasound-Enhanced Transdermal Drug Delivery
8. Metabolic Approach to Transdermal Drug Delivery
9. The Application of Supersaturated Systems to Percutaneous Drug Delivery
10. Minimally Invasive Systems for Transdermal Drug Delivery
11. Transdermal Drug Delivery System Regulatory Issues

Index

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