Normal and Malignant Development of Blood Cells
by Katya Ravid
and Jonathan Licht
Transcription Factors focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias.
Transcription Factors offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field.
In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as:
- Transcription factors and the megakaryocytic, myeloid, and erythroid lineages
- Leukemias due to chromosomal translocations involving gene encoding transcription factors
- Oncogenesis and hematopoiesis
- In vivo studies of transcription factors implicated in hematopoiesis
Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias.
Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Contents:
- The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation
- Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2
- Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis
- Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis
- EKLF and the Development of the Erythroid Lineage
- RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages
- PU.1 and the Development of the Myeloid Lineage
- CCAAT/Enhancer-Binding Proteins in Myeloid Cells
- Homeobox Gene Networks and the Regulation of Hematopoiesis
- The Role of Retinoic Acid Receptors in Myeloid Differentiation
- Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation
- The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation
- The Role of PU.1 in B-Lymphocyte Development and Function
- The Role of Pax5 (BSAP) in Early and Late B-Cell Development
- Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells
- E2A and the Development of B and T Lymphocytes
- The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas
- The Role of Octamer Factors and Their Coactivators in the Lymphoid System
- The Role of Early B-Cell Factor in B-Lymphocyte Development
- The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia
- The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11
- EVI1 Rearrangements in Malignant Hematopoiesis
- t(8;21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemias
- TEL/ETV6 Gene Rearrangements in Human Leukemias
- MLL in Normal and Malignant Hematopoiesis
- Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL
- The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis
- The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations
- The Roles of the c-myc and b-myb Oncogenes in Hematopoiesis and Leukemogenesis
- NF-kB in Cell Life and Death
- Transcription Factors Implicated in Hematopoiesis: In Vivo Studies
- Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma
Index
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