Hematology book from C.H.I.P.S.

Transcription Factors
Normal and Malignant Development of Blood Cells
by Katya Ravid
and Jonathan Licht

Transcription Factors focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias.

Transcription Factors offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field.

In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as:

  • Transcription factors and the megakaryocytic, myeloid, and erythroid lineages
  • Leukemias due to chromosomal translocations involving gene encoding transcription factors
  • Oncogenesis and hematopoiesis
  • In vivo studies of transcription factors implicated in hematopoiesis
Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias.

Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.


  1. The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation
  2. Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2
  3. Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis
  4. Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis
  5. EKLF and the Development of the Erythroid Lineage
  6. RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages
  7. PU.1 and the Development of the Myeloid Lineage
  8. CCAAT/Enhancer-Binding Proteins in Myeloid Cells
  9. Homeobox Gene Networks and the Regulation of Hematopoiesis
  10. The Role of Retinoic Acid Receptors in Myeloid Differentiation
  11. Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation
  12. The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation
  13. The Role of PU.1 in B-Lymphocyte Development and Function
  14. The Role of Pax5 (BSAP) in Early and Late B-Cell Development
  15. Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells
  16. E2A and the Development of B and T Lymphocytes
  17. The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas
  18. The Role of Octamer Factors and Their Coactivators in the Lymphoid System
  19. The Role of Early B-Cell Factor in B-Lymphocyte Development
  20. The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia
  21. The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11
  22. EVI1 Rearrangements in Malignant Hematopoiesis
  23. t(8;21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemias
  24. TEL/ETV6 Gene Rearrangements in Human Leukemias
  25. MLL in Normal and Malignant Hematopoiesis
  26. Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL
  27. The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis
  28. The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations
  29. The Roles of the c-myc and b-myb Oncogenes in Hematopoiesis and Leukemogenesis
  30. NF-kB in Cell Life and Death
  31. Transcription Factors Implicated in Hematopoiesis: In Vivo Studies
  32. Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma Index

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    Transcription Factors
    Normal and Malignant Development of Blood Cells
    by Katya Ravid and Jonathan Licht

    2001 • 622 pages • $241.00 + shipping
    Texas residents please add 6.75 % sales tax

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