Features of Textbook of Bladder Cancer:

• comprehensive reference, drawing on the expertise of international leaders in the field
• covers everything from epidemiology, pathology, and diagnosis to the treatment of both superficial and invasive bladder cancers
• contains more than 250 high quality color images

Contents

Epidemiology

1. Epidemiology of bladder cancer
2. Occupational risk factors
3. Familial bladder cancer
4. Genetic susceptibility to bladder cancer

Pathology

5. Urothelial carcinoma and its variants
6. WHO/ISUP grading system
7. Urothelial bladder tumor pathology
8. Non-urothelial tumors

Molecular Biology

9. Gene discovery
10. Molecular biology of bladder cancer: cell cycle alterations
11. Cytogenetics of urothelial neoplasis
12. Gene microarrays
13. Molecular biology of invasive and metastatic urothelial cancer
14. Animal models of bladder cancer
15. Animal models: naturally occurring canine urinary bladder cancer

Diagnosis

16. Cystoscopy
17. Florescence endoscopy
18. Imaging in the assessment of urinary bladder carcinoma
19. Cytology and DNA ploidy
20. Voided urine markers
21. Staging
22. Etiology and management of urothelial tumors of the renal pelvis and ureter
23. Early detection for bladder cancer
24. Natural history of stages Ta, T1, and Tis urothelial cancer in the urinary bladder
25. Risk stratification of Ta, Tis, T1 cancer
26. Issues in staging of Ta, Tis, T1 bladder cancers

Treatment

27. Transurethral resection of bladder tumors
28. Laser ablation and other technology
29. Perioperative instillation of chemotherapeutic drugs
30. The role of intravesical chemotherapy in the treatment of bladder cancer
31. Intravesical chemotherapy of superficial bladder cancer: optimization and novel agents
32. Intravesical immunothrapy: BCG
33. Mode of action of BCG and rationale for combination immunotherapy
34. Marker tumor concept: ethical issues
35. The use of the marker tumor concept in Ta, T1 bladder cancer: is it justified?
36. Photodynamic therapy
37. G3T1 bladder carcinoma
38. What to do when BCG fails
39. Chemoprevention of superficial bladder cancer
40. Surrogate endpoint biomarkers
41. Follow-up strategies in superficial bladder cancer

T2-4

42. The natural history of invasive bladder cancer
43. Selection and perioperative management of patients undergoing radical cystectomy and urinary reconstruction
44. Radical cystectomy—technique and outcomes
45. Cystectomy in the female
46. Nerve-sparing radical cystectomy
47. Laparoscopic radical cystectomy and urinary diversity
48. Role of extended pelvic lymphadenectomy
49. Role of sentinel node detection
50. Management of the urethra in the cystectomy patient
51. Rold of radical cystectomy in patients with unresectable and/or locoregionally metastatic bladder cancer

Primary Bladder Sparing Therapy

52. Radical TURBT
53. Partial cystectomy
54. Optimal radiotherapy for bladder cancer
55. Trimodality therapy in the management of muscle-invasive bladder cancer: a selective organ-preserving approach

Urinary Tract Reconstruction

56. Orthotopic neobladder
57. Continent cutaneous diversion
58. Noncontinent urinary diversion
59. Metabolic aspects of diversion
60. Psychosocial and quality-of-life issues
61. Tissue engineering of the bladder

Treatment of Regionally Advanced and Metastatic Bladder Cancer

62. Clinical trial design
63. Neo-adjuvant chemotherapy in the treatment of muscle-invasive bladder cancer
64. Adjuvant chemotherapy for invasive bladder cancer
65. Treatment of metastatic cancer
66. Special considerations in the elderly patient

Novel and Emerging Therapy

67. Targeted therapy for bladder cancer
68. Bladder cancer gene therapy

Treatment of Non-TCC

69. Treatment of non-TCC adenocarcinoma/sarcoma
70. Treatment of squamous cell carcinoma
71. Pediatric bladder tumors

Ancillary

72. Bladder cancer internet resources
73. Support groups
74. Education and counseling of the cystectomy patient

Index

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