Textbook of Bone Metastases presents a broad approach to recent progress in all fields related to bone metastases, ranging from epidemiology to the pathophysiology of bone metastases and therapeutics.

Features:

• Provides a better understanding of recent advances and, more importantly, will give clinicians all the information needed to help them in the clinical and therapeutic management of patients with bone metastases
• Includes an understanding of the molecular and cellular mechanisms involved in osteogenesis and osteolysis and their development for therapeutic purposes

Contents

Biology of Bone Mestases

• General mechanisms of metastasis
• Parathyroid hormone-related Protein and Bone metastases
• Osteoblastic Metastases
• The Role of RANK, RANK Ligand and Osteoprotegerin in the Lytic Effects and Growth of Bone Metastases

Clinical Features and Assessment

• Clinical Features and Prognosis of Bone Metastases
• Radio-isotope and PET Imaging of Bone Metastases
• Imaging of Spinal Bone Metastases
• Monitoring Response to Treatment - the Role of Biochemical Markers
• Surgical Biopsy of Bone Metastases

Surgical Treatment

• Indications for the Surgical Treatment of Long Bone Metastases
• Prosthetic Replacement in Long Bone Metastases
• Osteosynthesis for Pathological Fractures in Long Bones
• Surgical Treatment of Pelvic Metastases
• Indications and Strategy for the Treatment of Spinal Metastases
• Surgical Techniques for the Treatment of Bone Metastases of the Spine
• Total En Bloc Spondylectomy for Spinal Metastases

Local Treatments

• External Beam Radiation Therapy for the Treatment of Bone Metastases
• Interventional Radiology for Bone Metastases
• Percutaneous Injection of Ethanol

Systemic Treatments

• Chemotherapy
• Endocrine Treatment of Bone Metastases
• Overview of Osteoclast Inhibitors
• Radioisotopes and Radioimmunoisotopes
• Immunotherapy

Bisphosphonates

• Mechanisms of Action of Bisphosphonates
• Antitumor Effects of Bisphosphonates
• Management of Hypercalcaemia
• Treatment of Lytic Bone Metastases
• Use in Multiple Myeloma
• Use in Prostate Cancer
• Prevention of Bone Metastases
• Prevention of Bone Loss
• Cost Implications of Bisphosphonates

The Global Approach

• Treatment of Bone Pain
• Specific Approaches to Cancer in the Elderly
• Psychological and Social Aspects
• Metabolic Bone Diseases in Childhood Cancer

Bone Mesastases in Specific Tumours

• Breast Cancer
• Prostate Cancer
• Multiple Myeloma
• Malignant Non-Hodgkin’s Lymphoma
• Lung Cancer
• Kidney Cancer
• Evaluation of the Patient with Bone Metastases at Presentation

Index

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