Medical Science Book from C.H.I.P.S.

Textbook of Epilepsy Surgery
by Hans Luders

Textbook of Epilepsy Surgery will cover all of the latest advances in the surgical management of epilepsy, including:

  • new neuroimaging techniques
  • new surgical strategies
  • more aggressive surgical approaches in cases with catastrophic epilepsies
  • better understanding of epileptogenic mechanisms in etiologically different types of epilepsy
  • new surgical techniques and neuronavigation systems
  • improved statistics of surgical outcome in different epilepsy types
Textbook of Epilepsy Surgery is an invaluable tool and reference source for neurologists, neurosurgeons, epilepsy specialists and those interested in epilepsy and its surgical treatment.


History of Surgery and Related Fields

  1. Epilepsy surgery in Europe before the 19th century
  2. Epilepsy surgery in Asia before the 19th century
  3. Epilepsy surgery in Latin America before the 19th century
  4. Epilepsy surgery in Germany
  5. Epilepsy surgery in France
  6. Epilepsy surgery in Italy
  7. Epilepsy surgery in Switzerland
  8. Epilepsy surgery in Austria
  9. Epilepsy surgery in the Nordic countries
  10. The development of epilepsy surgery in the Netherlands and Belgium
  11. History of epilepsy surgery in the Middle- and East-European countries and Russia
  12. Epilepsy surgery in Canada
  13. A brief history of epilepsy surgery in the United States
  14. Epilepsy surgery in Latin America
  15. Epilepsy surgery in Africa
  16. History of epilepsy surgery in Southeast Asia
  17. Treatment of epilepsy in Australia
  18. Epilepsy surgery in Korea
  19. Epilepsy surgery in Thailand
  20. History of epilepsy and seizure classification
  21. History of electroencephalography as a presurgical evaluation tool: the pre-Berger years
  22. History of neuroimaging in the presurgical evaluation
  23. Epilepsy surgery in literature and film
  24. The future of epilepsy surgery
  1. Medical intractability in epilepsy
  2. Epidemiology of the intractable generalized epilepsies
  3. Genetic factors contributing to medically intractable epilepsy
  4. Informed consent
  5. Epilepsy surgery: access, costs, and quality of life
  6. Epilepsy surgery: patient selection
  7. Exclusion criteria
Epilepsies Remediable by Epilepsy Surgery
  1. Classification of epileptic seizures and epilepsies
  2. Mesial temporal sclerosis
  3. Neocortical temporal lobe epilepsy
  4. Premotor and central lobe epilepsy
  5. Mesial frontal epilepsy
  6. Basal frontal lobe epilepsy
  7. Parieto-occipital lobe epilepsy
  8. Insular epilepsy
  9. Cingulate epilepsy
  10. Hypothalamic hamartomas
  11. Rasmussen syndrome
  12. The Landau–Kleffner syndrome
  13. The Lennox–Gastaut syndrome: a surgically remediable epilepsy?
  14. Medically intractable epilepsies not remediable by surgery
  15. Special characteristics of surgically remediable epilepsies in infants
Pre-Surgical Evaluation: General Principles
  1. General principles of pre-surgical evaluation
The Symptomatogenic Zone
  1. The symptomatogenic zone – general principles
  2. Auras: localizing and lateralizing value
  3. Autonomic seizures: localizing and lateralizing value
  4. Simple motor seizures: localizing and lateralizing value
  5. omplex motor seizures: localizing and lateralizing value
  6. Dialeptic seizures: localizing and lateralizing value
  7. Special seizures: localizing and lateralizing value
  8. The irritative zone: general principles
  9. Noninvasive electroencephalography evaluation of the irritative zone
  10. The irritative zone evaluated with invasive recordings
  11. The significance of interictal fast ripples in the evaluation of the epileptogenic zone
  12. Magnetoencephalography in the evaluation of the irritative zone
  13. agnetic resonance imaging in the evaluation of the irritative zone
  14. Digital tools for reviewing the electroencephalogram: montage reformatting and filtering
  15. Average reference and Laplacian montages
  16. Automatic detection of epileptic spikes
  17. Source localization of electroencephalography spikes
  18. Antiepileptic drug withdrawal in presurgical evaluation: advantages, disadvantages, and guidelines
  19. Effects of sleep and sleep deprivation on seizures and the electroencephalography in epilepsy
The Ictal Onset Zone
  1. The ictal onset zone: general principles, pitfalls, and caveats
  2. Noninvasive electroencephalography in the evaluation of the ictal onset zone
  3. Indications for invasive electroencephalography evaluations
  4. Invasive electrodes in long-term monitoring
  5. Foramen ovale and epidural electrodes in the definition of the seizure onset zone
  6. Subdural electrodes
  7. Stereoelectroencephalography
  8. DC recordings to localize the ictal onset zone
  9. fMRI in the evaluation of the ictal onset zone
  10. Ictal SPECT in the definition of the seizure onset zone
  11. Automatic detection of epileptic seizures
  12. ‘Preictal’ predictors of epileptic seizures
  13. Effect of anticonvulsant withdrawal on seizure semiology and ictal electroencephalography
  14. Zone of electrical stimulation induced seizures in subdural electrodes
The Epileptic Lesion
  1. The epileptogenic lesion: general principles
  2. Magnetic resonance imaging in epilepsy: mesial temporal sclerosis
  3. Magnetic resonance imaging in neurocutaneous syndromes
  4. Magnetic resonance imaging in epileptogenic neoplasms
  5. Magnetic resonance spectroscopy in patients with epilepsy
  6. Post-processing of the magnetic resonance imaging to better define structural abnormalities
The Functional Deficit Zone
  1. The functional deficit zone: general principles
  2. Mesial temporal lobe epilepsy and positron emission tomography
  3. PET in neocortical epilepsies
  4. Pre-surgical neuropsychological workup: risk factors for post-surgical deficits
  5. Pre-surgical psychiatric evaluations: risk factors for post-surgical deficits
  6. Pre-surgical neuropsychological workup in children and intellectually disabled adults with epilepsy
  7. Wada test and epileptogenic zone
  8. Event-related potentials in patients with epilepsy
Pre-Surgical Evaluation of Eloquent Cortex
  1. Eloquent cortex and tracts: overview and noninvasive evaluation methods
  2. Noninvasive tests to define lateralization or localization of the motor area
  3. Noninvasive tests to define lateralization or localization of memory
The Epileptogenic Zone
  1. The epileptogenic zone: general principles
  2. Future methods for the direct assessment of the epileptogenic zone
The Patient Management Meeting
  1. The patient management conference
Surgical Techniques for Placement of Intracranial Electrodes
  1. Anesthesia for epilepsy surgery
  2. Placement of subdural grids
  3. Placement of depth electrodes
  4. Stereoelectroencephalography
Cortical Mapping and Electrocorticography
  1. General principles of cortical mapping by electrical stimulation
  2. Cortical mapping by electrical stimulation of subdural electrodes: primary somatosensory and motor areas
  3. Cortical mapping by electric stimulation of subdural electrodes: negative motor areas
  4. Cortical mapping by electrical stimulation of subdural electrodes: supplementary sensorimotor area in humans
  5. Cortical mapping by electrical stimulation of subdural electrodes: language areas
  6. Cortical mapping by electrical stimulation: other eloquent areas
  7. The role of electroencephalogram and magnetoencephalography synchrony in defining eloquent cortex
  8. Cortical mapping using evoked potentials and Bereitschaftspotentials
  9. Cortico-cortical evoked potentials to define eloquent cortex
  10. Functional localization of the cortex with depth electrodes
  11. Intraoperative cortical mapping and intraoperative electrocorticography
Resective Surgical Procedures for Epilepsy
  1. Resective surgical techniques: mesial temporal lobe epilepsy
  2. Resective neocortical techniques in adults
  3. Epilepsy and vascular malformations: spectrum of lesions and strategies for management
  4. Resective neocortical techniques in children
  5. Hemispherectomy techniques
Nonresective Surgical Procedures and Electrical or Magnetic Stimulation for Epilepsy Treatment
  1. Experimental multiple subpial transection: is it still indicated?
  2. Multiple subpial transections
  3. Corpus callosotomy
  4. Radiosurgical treatment of epilepsy
  5. Vagal nerve stimulation: experimental data
  6. Vagal nerve stimulation: surgical technique and complications
  7. Vagus nerve stimulation: human studies
  8. Experimental evidence for the involvement of the basal ganglia in the control of epilepsy
  9. Repetitive transcranial magnetic stimulation
Surgical Outcome
  1. Mesial temporal lobectomy: post-surgical seizure frequency
  2. Resective surgery in children
  3. Hemispherectomy: post-surgical seizure frequency
  4. Psychiatric outcome of epilepsy surgery
  5. Psychosocial outcome and quality of life outcome
  6. Neuropsychological outcome
  7. Temporal lobe epilepsy surgery: surgical complications
  8. Neocortical focal epilepsy surgery: surgical complications
Post-Surgical Management
  1. Early post-surgical management of patients with epilepsy
  2. Post-surgical pharmacotherapy: discontinuation of anticonvulsants
  3. Post-surgical rehabilitation
Neuropathology and Research Related to Epilepsy Surgery
  1. Neuropathology of mesial temporal sclerosis
  2. Pathology of neocortical epilepsy
  3. Pathology of malformations of cortical development
  4. athology of neurocutaneous abnormalities, vascular abnormalities: post-infectious and post-traumatic pathologies associated with epilepsy
  5. Pathology of epileptogenic neoplasms
  6. In vitro neurophysiological studies
  7. In vitro cytochemical studies in epilepsy
  8. Animal models of epilepsy with special reference to models relevant for transitional research
Surgical Failure: Reoperation
  1. Surgical failures: pre-surgical evaluation
  2. Reoperation after failed epilepsy surgery
Case Presentations
  1. Lesional mesial temporal epilepsy: case discussions
  2. A patient with nonlesional mesial temporal lobe epilepsy
  3. Patient with bitemporal lobe epilepsy
  4. Patient with lesional neocortical focal epilepsy
  5. Patient with nonlesional neocortical epilepsy
  6. Patient with extensive malformation of cortical development
  7. Hemispherectomy in a patient with catastrophic epilepsy
  8. Case studies: Landau–Kleffner syndrome
  9. Deep brain stimulation in a patient with medically intractable generalized seizures
  10. Successful transcranial magnetic stimulation in a patient with medically intractable focal epilepsy
  11. Surgery in a patient with medically intractable gelastic seizures and a hypothalamic hamartoma
  12. Surgery in a patient with focal epilepsy and dual pathology
  1. Essentials for the establishment of an epilepsy surgery program
  2. Classification of seizure outcome following epilepsy surgery
  3. Protocol for storage and processing of brain tissue for molecular studies

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Textbook of Epilepsy Surgery
by Hans Luders
2009 • 2,000 pages • $679.95 + shipping
Texas residents please add 6.75 % sales tax

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