Textbook of Hemophilia is an invaluable resource for all those managing hemophilia patients. It covers all the common and rare bleeding disorders, both in terms of clinical management as well as the genetic, laboratory, financial and psychological aspects.

Covers:

• how to assess both bleeding children and adults
• Haemophilia A and B
• molecular basis of the disease
• the role of factors in coagulation
• epidemiology
• pharmacokinetics
• treatment of inhibitors

This second edition covers all the latest developments in the field of hemophilia, with new chapters on:

• the genetic and molecular basis of inherited blood disorders
• how to manage adolescent and older patients
• emergency medicine and inherited blood disorders
• national hemophilia databases

Contents

Part I: Introduction

1. Overview of Hemostasis
2. Cellular processing of Factor VIII and Factor IX

Part II: Hemophilia A

3. Molecular Basis of Hemophilia A
4. Phenotypic/genotypic relationship
5. Prophylaxis
6. Continuous Infusion of Coagulation Products in Hemophilia

Part III: Inhibitors to Factor VIII

7. Inhibitors to Factor VIII - Immunology
8. Genetic and environmental risk factors for FVIII inhibitor development
9. Inhibitors to Factor VIII - Mild and Moderate Hemophilia
10. Inhibitors to Factor VIII/IX: Immune Tolerance
11. Inhibitors to factor VIII: treatment of acute bleeds

Part IV: Acquired Hemophilia

12. Acquired Inhibitors to Factor VIII

Part V: Hemophilia B

13. Hemophilia B - Molecular Basis
14. Factor IX Inhibitors in Hemophilia B
15. Treatment of Inhibitors in Hemophilia B

Part VI: Pharmacokinetics of Factors VIII & IX

16. Pharmacokinetics

Part VII: Hemophilia - birth to old age

17. The Neonate with Hemophilia
18. Work-up of a Bleeding Child
19. Care of the Child with Hemophilia
20. Adolescence
21. Old age medicine and hemophilia

Part VIII: Products used to Treat Hemophilia

22. Products Used to Treat Hemophilia: Recombinant Products
23. Products Used to Treat Hemophilia: Plasma-Derived Coagulation Factor Concentrates
24. Products Used to Treat Hemophilia: Recombinant Factor VIIa
25. Products Used to Treat Hemophilia: Dosing
26. Products Used to Treat Hemophilia: Regulation

Part IX: Musculoskeletal

27. Joint Replacement
28. Synovioarthesis in Hemophilia
29. Pseudotumours in patients with Hemophilia
30. Imaging modalities for assessment of hemophilic arthropathy
31. Physiotherapy in the Management of Hemophilia
32. Clinimetric Instruments in Haemophilia

Part X: Transfusion-Transmitted Disease

33. Hepatitis C Virus Infection and Liver Transplantation
34. Emerging Infections

Part XI: Gene Therapy

35. Hemophilia Gene Therapy
36. Gene Therapy Trials
37. Gene Therapy: Molecular Engineering of Factor VIII and Factor IX

Part XII: Laboratory

38. Laboratory Assays in Hemophilia
39. Standardization of Assays
40. Global laboratory assays in Haemophilia

Part XIII: Obstetrics & Gynaecology

41. Obstetrics and Gynecology: Hemophilia

Part XIV: Von Willebrand Disease

42. von Willebrand Disease: Molecular Aspects
43. von Willebrand Disease: Epidemiology
44. von Willebrand Disease: Biological Diagnosis
45. Classification and Clinical Aspects of von Willebrand Disease

Part XV: Treatment of Von Willebrand Disease

46. Treatment of von Willebrand Disease: Desmopressin
47. Treatment of von Willebrand Disease: Therapeutic Concentrates
48. Women & Von Willebrand Disease

Part XVI: Rare Bleeding Disorders

49. Factor II
50. Factor V and combined Factor V and VIII Deficiencies
51. Congenital Factor VII Deficiency
52. Factor X Deficiency
53. Factor XI Deficiency
54. Factor XIII Deficiency
55. Fibrinogen Deficiency
56. Miscellaneous Rare Bleeding Disorders

Part XVII: Emergency medicine

57. Emergency Medicine and Inherited Blood Disorders

Part XVIII: Quality of Life

58. Quality of Life in Hemophilia

Part XIX: Economics

59. The Economics of Hemophilia Treatments

Part XX: Comprehensive Care and Delivery of Care

60. National Haemophilia Databases
61. Comprehensive Care and the Delivery of Care: The Developed World
62. Comprehensive care and delivery of care in haemophilia: The Developing World
63. Comprehensive Care and Delivery of Care: The Global Perspective

Index

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