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Textbook of the Neurogenic Bladder
Second Edition
by Nyle C. Brady

Textbook of the Neurogenic Bladder covers all aspects of the neurogenic bladder from aetiology and pathophysiology to diagnosis and treatment of all associated problems.

This evidence-based text is an essential reference source for residents, physicians, and healthcare professionals involved in the diagnosis and management of neurogenic bladder patients.

With over 300 superbly illustrated images that clarify the differing states of neurogenic bladder dysfunction, Textbook of the Neurogenic Bladder expands on the strong reputation of the first edition to highlight the new diagnostic techniques that have emerged to complement traditional management.

These major advances range from non-surgical, electrical, and surgical treatments to neurostimulation and tissue engineering.


The normal genito-urinary tract

  1. Embryology of the lower urinary tract
  2. Simplified anatomy of the vesico–urethral functional unit
  3. Physiology of the urothelium
  4. Physiology of the smooth muscles of the bladder and urethra
  5. Physiology of the striated muscles
  6. Pharmacology of the lower urinary tract
  7. Integrated physiology of the lower urinary tract
  8. Physiology of normal sexual function
Functional pathology of the lower urinary tract
  1. Epidemiology of the neurogenic bladder
  2. Ultrastructure of neurogenic bladders
  3. Pathophysiology of the overactive bladder
  4. Pathophysiology of detrusor underactivity/acontractile detrusor
  5. Pathophysiology of the low compliant bladder
  6. Pathophysiology of the vesico-sphincteric dyssynergia
  7. Pathophysiology of the autonomic dysreflexia
  8. Pathophysiology of spinal shock
Neurologic pathologies responsible for the development of the neurogenic bladder

Peripheral neuropathies

  1. Systemic illnesses (diabetes mellitus, sarcoidosis, alcoholism, and porphyrias)
  2. Other peripheral neuropathies (lumbosacral zoster, genitourinary herpes, tabes dorsalis, Guillain–Barré syndrome)
  3. Peripheral neuropathies of the lower urinary tract following pelvic surgery and radiation therapy
Hereditary and degenerative diseases
  1. Dementia and lower urinary tract dysfunction
  2. Pathologies of the basal ganglia, such as Parkinson’s and Huntington’s disease
  3. Urinary dysfunction in multiple system atrophy
Demyelinatinq neuropathies
  1. Multiple sclerosis
  2. Other diseases (transverse myelitis, tropical spastic paraparesis, progressive multifocal leukoencephalopathy, Lyme’s disease)
Vascular pathologies and tumors of the brain
  1. Cerebrovascular accidents, intracranial tumors, and urologic consequences
Disc prolapse and tumors of the spinal cord
  1. Intervertebral disc prolapse
  2. The cauda equina syndrome
  3. Tumors of the spinal cord
  4. Tethered cord syndrome
Traumatic injuries of the central nervous system
  1. Spinal cord injury and cerebral trauma
Other neurologic pathologies responsible for neurogenic bladder dysfunction
  1. Cerebral palsy, cerebellar ataxia, AIDS, phacomatosis, neuromuscular disorders, and epilepsy
  2. Syringomyelia and lower urinary tract dysfunction
Evaluation of neurogenic bladder dysfunction
  1. Clinical evaluation: history and physical examination
  2. The voiding diary
  3. The pad-weighing test
  4. Endoscopic evaluation of neurogenic bladder
  5. lmaging techniques in the evaluation of neurogenic bladder dysfunction
  6. Evaluation of neurogenic bladder dysfunction: basic urodynamics
  7. Advanced urodynamics
  8. Normal urodynamic parameters in children
  9. Urodynamics in infants and children
  10. Normal urodynamic parameters in adults
  11. Electrophysiologic evaluation: basic principles and clinical applications
  12. Practical guide to diagnosis and follow-up of patients with neurogenic bladder dysfunction
  1. Classification of lower urinary tract dysfunction


  1. Conservative treatment
  2. Management of neurogenic bladder with suprapubic cystostomy
  3. Systemic and intrathecal pharmacologic treatment
  4. Intravesical pharmacologic treatment for neurogenic detrusor overactivity
  5. Transdermal oxybutynin administration
  6. Management of autonomic dysreflexia
  1. Peripheral electrical stimulation
  2. Emptying the neurogenic bladder by electrical stimulation
  3. Central neuromodulation
  4. Intravesical electrical stimulation of the bladder
  1. Surgery to improve reservoir function
  2. Surgery to improve bladder outlet function
  3. Urinary diversion
  4. The trans-appendicular continent cystostomy technique (Mitrofanoff principle)
Future developments
  1. Tissue engineering and cell therapies for neurogenic bladder augmentation and urinary continence restoration
  2. Restoration of complete bladder function by neurostimulation
  3. Neuroprotection and repair after spinal cord injury
Special considerations on meningo-myelocele
  1. Neural tube defects: etiology, prevention, and prenatal diagnosis
  2. Initial management of meningo-myelocele children
  3. Intravesical electrical stimulation in new-born infants and children
  4. Fecal incontinence management in the neurogenic bladder patient
  5. Adult meningo-myelocele
Synthesis of treatment
  1. The vesicourethral balance
  2. Treatment alternatives for different types of neurogenic bladder dysfunction in children
  3. Treatment alternatives for different types of neurogenic bladder dysfunction in adults: an overview
  1. Complications related to neurogenic bladder dysfunction – I: infection, lithiasis, and neoplasia
  2. Complications related to neurogenic bladder dysfunction – II: reflux and renal insufficiency
  3. Benign prostatic hyperplasia and lower urinary tract symptoms in men with neurogenic bladder
Sexual dysfunction in neurologic disorders
  1. Pathophysiology of male sexual dysfunction after spinal cord injury
  2. Sexual dysfunction in patients with multiple sclerosis and other neurologic diseases
  3. Treatment modalities for erectile dysfunction in neurologic patients
  4. Fertility issues in men with spinal cord injury
  5. Pregnancy in spinal cord injury
Prognosis and follow-up
  1. Evolution and follow-up of lower urinary tract dysfunction in spinal cord injury patients
  2. Neurogenic bladder surveillance in children
  3. Considerations on the international data set on lower urinary tract function following spinal cord injury
Ethical considerations
  1. Ethical considerations in neurogenic lower urinary tract dysfunction
Reports and guidelines
  1. Reports and guidelines in relation to neurogenic bladder dysfunction: a selection

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Textbook of the Neurogenic Bladder
Second Edition
by Nyle C. Brady

2008 • 928 pages • $725.00 + shipping
Texas residents please add 6.75 % sales tax

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